{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:52:21Z","timestamp":1789638741474,"version":"4.0.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the grade of endolymphatic hydrops in patients with \u201cprobable\u201d and \u201cdefinite\u201d M\u00e9ni\u00e8re\u2019s disease via magnetic resonance imaging (MRI) and to determine whether MRI could assist clinicians in differential diagnosis between probable and definite M\u00e9ni\u00e8re\u2019s disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Three\u2010dimensional FLAIR MRI (fluid\u2010attenuated inversion recovery) to examine endolymphatic hydrops in M\u00e9ni\u00e8re\u2019s disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 51 patients diagnosed with probable (n = 20) or definite (n = 31) unilateral M\u00e9ni\u00e8re\u2019s disease were enrolled. Three\u2010dimensional FLAIR MRI was performed to evaluate the grade of endolymphatic hydrops. The differences in endolymphatic hydrops between the probable and definite groups were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The grade of endolymphatic hydrops was more severe in the definite group than in the probable group (<jats:italic>P<\/jats:italic> &lt;. 05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MRI revealed a higher grade of endolymphatic hydrops in patients with definite M\u00e9ni\u00e8re\u2019s disease than in patients with probable M\u00e9ni\u00e8re\u2019s disease. As a result, it may be clinically useful and an effective tool in the differentiation between definite and probable M\u00e9ni\u00e8re\u2019s disease.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599821990680","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T15:55:10Z","timestamp":1612281310000},"page":"696-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Differential Diagnosis of Endolymphatic Hydrops Between \u201cProbable\u201d and \u201cDefinite\u201d M\u00e9ni\u00e8re\u2019s Disease via Magnetic Resonance Imaging"],"prefix":"10.1002","volume":"165","author":[{"given":"Jiapei","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Radiology The Fourth Affiliated Hospital of China Medical University Shenyang 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