{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:15:07Z","timestamp":1787616907700,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["K08DC018575"],"award-info":[{"award-number":["K08DC018575"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>Age\u2010related hearing loss (presbycusis) is a prevalent condition attributed primarily to inner ear dysfunction. Little is known about age\u2010related changes in the ossicular joints or their contribution to presbycusis. Herein, we performed a histopathologic analysis of the incudomalleolar joint (IMJ) in specimens from the National Temporal Bone Registry with audiometrically confirmed presbycusis but without histologically observed sensory, neural, strial, or mixed features. Seventeen \u201cindeterminate\u201d presbycusis (IP) ears and 13 young, normal\u2010hearing ears were examined. The age was 73.2 \u00b1 9.5 years for the IP group and 32.1 \u00b1 9.5 for the young group (<jats:italic>P<\/jats:italic> &lt;. 05). The joint space between the 2 ossicles was 23% wider in the IP group (139 \u00b1 26.2 \u00b5m) compared to young ears (113 \u00b1 49.0 \u00b5m) (<jats:italic>P<\/jats:italic> =. 02). We report that IP ears have a wider IMJ than young ears. These findings have implications for understanding the etiology of presbycusis in indeterminate cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence:<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599821993813","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T04:04:03Z","timestamp":1614053043000},"page":"701-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Histopathology of the Incudomalleolar Joint in Cases of \u201cIndeterminate\u201d Presbycusis"],"prefix":"10.1002","volume":"165","author":[{"given":"Prithwijit","family":"Roychowdhury","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Massachusetts Eye and Ear Harvard University Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery UMASS Memorial Medical Center University of Massachusetts Medical School Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Castillo\u2010Bustamante","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Massachusetts Eye and Ear Harvard University Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Polanik","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Massachusetts Eye and Ear Harvard University Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery UMASS Memorial Medical Center University of Massachusetts Medical School Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott D.","family":"Kozin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Massachusetts Eye and Ear Harvard University Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron K.","family":"Remenschneider","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Massachusetts Eye and Ear Harvard University Boston Massachusetts USA"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery UMASS Memorial Medical Center University of Massachusetts Medical School Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31363-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.134"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1964.00750040381003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894931020S101"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.03.022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200604000-00005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988910000105"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770030761019"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947408300109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1808221"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00332-0"},{"key":"e_1_2_9_13_1","first-page":"4","volume-title":"Pathology 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