{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T05:45:23Z","timestamp":1772257523579,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011912","name":"washington university school of medicine in st. louis","doi-asserted-by":"publisher","award":["Office of Medical Student Research"],"award-info":[{"award-number":["Office of Medical Student Research"]}],"id":[{"id":"10.13039\/100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effectiveness of cognitive training in improving tinnitus bother and to identify predictors of patient response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective open\u2010label randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Online.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were adults with subjective idiopathic nonpulsatile tinnitus causing significant tinnitus\u2010related distress. The intervention group trained by using auditory\u2010intensive exercises for 20\u00a0minutes per day, 5\u00a0days per week, for 8 weeks. The active control group trained on the same schedule with non\u2013auditory intensive games. Surveys were completed at baseline, 8 weeks, and 12 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 64 participants completed the study. The median age was 63 years (range, 25\u201069) in the intervention group and 61 years (34\u201068) in the control group. Mixed model analysis revealed that within\u2010subject change in Tinnitus Functional Index in the intervention group was not different than the control group, with marginal mean differences (95% CI): 0.24 (\u201311.20 to 10.7) and 2.17 (\u20138.50 to 12.83) at 8 weeks and 2.33 (\u20138.6 to 13.3) and 3.36 (\u20137.91 to 14.6) at 12 weeks, respectively. When the 2 study groups were compared, the control group had higher Tinnitus Functional Index scores than the intervention group by 10.5 points at baseline (95% CI, \u20130.92 to 29.89), 8.1 at 8 weeks (95% CI, \u20133.27 to 19.42), and 9.4 at 12 weeks (95% CI, \u20132.45 to 21.34).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Auditory\u2010intensive cognitive training was not associated with changes in self\u2010reported tinnitus bother. Given the potential for neuroplasticity to affect tinnitus, we believe that future studies on cognitive training for tinnitus remain relevant.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0194599821994742","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T11:37:39Z","timestamp":1614685059000},"page":"854-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigating the Impact of Cognitive Training for Individuals With Bothersome Tinnitus: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"165","author":[{"given":"Maggie","family":"Xing","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University School of Medicine St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorina","family":"Kallogjeri","sequence":"additional","affiliation":[{"name":"Department of 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