{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:33:07Z","timestamp":1777620787777,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Anxiety and depression have demonstrated a positive correlation with vocal handicap among patients with benign causes of dysphonia. Our objective is to explore differences in initial Vocal Handicap Index\u201310 (VHI\u201010) scores between patients with a mental health history of anxiety or depression and those without.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Demographic data, diagnoses, and initial VHI\u201010 scores were collected for patients presenting with dysphonia to 2 tertiary laryngology clinics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Kruskal\u2010Wallis test and subsequent Mann\u2010Whitney <jats:italic>U<\/jats:italic> test for pairwise comparisons were used to compare distribution of VHI\u201010 scores among patients with anxiety, depression, anxiety and depression, and no such conditions. Bonferroni correction was used to control for multiple comparisons. Robust regression was used for multivariable analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 620 cases of benign dysphonia were analyzed. Forty\u2010two percent of the patient cohort had a preexisting diagnosis of anxiety (n = 121, 20%), depression (n = 64, 10%), or anxiety and depression (n = 74, 12%). VHI\u201010 scores were higher in patients with depression than in those without anxiety or depression (median difference, 4 [95% CI, 1\u20108]; <jats:italic>P<\/jats:italic> =. 005) but did not differ significantly among the other groups. The effects of depression and anxiety status on initial VHI\u201010 scores among the causes of benign dysphonia varied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with a history of depression who presented with dysphonia had worse vocal handicap than those without anxiety\/depression history. Future studies may clarify how optimization of anxiety and depression can affect patient\u2010reported vocal handicap.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998221074994","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T12:04:24Z","timestamp":1643717064000},"page":"725-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Correlation Between a Diagnosis of Anxiety or Depression and Initial VHI\u201010 Scores in Benign Dysphonia"],"prefix":"10.1002","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5973-9027","authenticated-orcid":false,"given":"Kwasi","family":"Enin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University School of Medicine in St Louis St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayush","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorina","family":"Kallogjeri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University School of Medicine in St Louis St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Naunheim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly N.","family":"Huston","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University School of Medicine in St Louis St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"US Department of Health and Human Services","author":"Mental Illness","year":"2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25819"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2006.08.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.4414\/smw.2005.10346","article-title":"Stress and distress in non\u2010organic voice disorder","volume":"135","author":"Seifert E","year":"2005","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324641"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2014.02.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.1621"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(99)80010-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948209100409"},{"key":"e_1_2_10_11_1","first-page":"858","article-title":"The treatment gap in mental health care","volume":"82","author":"Kohn R","year":"2004","journal-title":"Bull World Health Organ"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28216"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28148"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7314.658"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812465592"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/01945998221074994","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/01945998221074994","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/01945998221074994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:34:05Z","timestamp":1760963645000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/01945998221074994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1177\/01945998221074994"],"URL":"https:\/\/doi.org\/10.1177\/01945998221074994","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"2021-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}