{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:10:02Z","timestamp":1790424602239,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Traditionally, data regarding thyroidectomy were extracted from billing databases, but information may be missed. In this study, a multi\u2010institutional pediatric thyroidectomy database was used to evaluate recurrent laryngeal nerve (RLN) injury and hypoparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective multi\u2010institutional cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care pediatric hospital systems throughout North America.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were individually collected for thyroidectomies, then entered into a centralized database and analyzed using univariate and multivariable regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 1025 thyroidectomies from 10\u00a0institutions were included. Average age was 13.9 years, and 77.8% were female. Average hospital stay was 1.9\u00a0nights and 13.5% of patients spent at least 1\u00a0night in the pediatric intensive care unit. The most frequent pathology was papillary thyroid carcinoma (42%), followed by Graves\u2019 disease (20.1%) and follicular adenoma (18.2%). Overall, 1.1% of patients experienced RLN injury (0.8% permanent), and 7.2% experienced hypoparathyroidism (3.3% permanent). Lower institutional volume (odds ratio [OR], 3.57; 95% CI, 1.72\u20107.14) and concurrent hypoparathyroidism (OR, 3.51; 95% CI, 1.64\u20107.53) correlated with RLN injury on multivariable analysis. Graves\u2019 disease (OR, 2.27; 95% CI, 1.35\u20103.80), Hashimoto\u2019s thyroiditis (OR, 4.67; 95% CI, 2.39\u20109.09), central neck dissection (OR, 3.60; 95% CI, 2.36\u20105.49), and total vs partial thyroidectomy (OR, 7.14; 95% CI, 4.55\u201011.11) correlated with hypoparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data present thyroidectomy information and complications pertinent to surgeons, along with preoperative risk factor assessment. Multivariable analysis showed institutional volume and hypoparathyroidism associated with RLN injury, while hypoparathyroidism associated with surgical indication, central neck dissection, and extent of surgery. Low complication rates support the safety of thyroidectomy in pediatric tertiary care centers.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998221076065","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T12:08:31Z","timestamp":1644322111000},"page":"869-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Outcomes in Pediatric Thyroidectomy: Results From a Multinational, Multi\u2010institutional Database"],"prefix":"10.1002","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-8403","authenticated-orcid":false,"given":"Matthew","family":"Maksimoski","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Bauer","sequence":"additional","affiliation":[{"name":"The Thyroid Center Division of Endocrinology and Diabetes Children\u2019s Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kazahaya","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology Children\u2019s Hospital of Philadelphia Department of Otolaryngology\u2013Head and Neck Surgery University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Washington Seattle Children\u2019s Hospital Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay R.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Washington Seattle Children\u2019s Hospital Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P.","family":"Simons","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology UPMC Children\u2019s Hospital of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology Children\u2019s Hospital of New Orleans and Louisiana State University New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Maddalozzo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"},{"name":"Division of Pediatric Otolaryngology Ann &amp; Robert H Lurie Children\u2019s Hospital of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Purkey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Rychlik","sequence":"additional","affiliation":[{"name":"Stanley Manne Children\u2019s Research Institute Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Rutter","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California, San Diego Division of Otolaryngology Rady Children\u2019s Hospital San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Prager","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology University of Colorado School of Medicine Children\u2019s Hospital of Colorado Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Diercks","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan J.","family":"Propst","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Hospital for Sick Children University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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