{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:31:45Z","timestamp":1793979105574,"version":"4.8.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Acinic cell carcinoma (AciCC) is a rare, usually low\u2010grade salivary malignancy. Evidence on rates of lymph node metastases (LNMs) is limited in pediatric patients and varies significantly (4%\u201045%) in adults. We set out to determine and compare rates of LNMs in pediatric and adult AciCC and to analyze their impact on survival, using the National Cancer Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Historical cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>National Cancer Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All AciCCs of the major salivary glands with complete clinical and pathologic nodal staging were selected between 2010 and 2016. Patient demographics, tumor characteristics, treatment, and survival were analyzed. Univariable and multivariable regression were performed to determine factors associated with LNMs and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 57 (4.6%) pediatric patients (&lt;18 years) and 1192 (95.4%) adults with AciCC. Clinical LNMs were rare in pediatric patients (n &lt; 10) and adults (n = 88, 7.4%). Occult LNMs were uncommon in pediatric patients (n &lt; 5) and adults (n = 41, 4.6%). Three\u2010year overall survival for pediatric patients was 97.8%. Adults with LNM had worse 3\u2010year overall survival than those without (66.0% vs 96.3%, <jats:italic>P<\/jats:italic> &lt;. 001). In multivariable regression, high\u2010grade disease (hazard ratio, 10.15 [95% CI, 5.60\u201018.80]; <jats:italic>P<\/jats:italic> &lt;. 001) and T3\u2010T4 tumors (hazard ratio, 2.80 [95% CI, 1.56\u20104.97]; <jats:italic>P<\/jats:italic> &lt;. 001) were associated with LNM in adult patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LNMs in AciCC of the major salivary glands are rare in children and adults. However, high\u2010grade and T3\u2010T4 tumors are associated with an increased risk of LNM. LNM is associated with worse survival.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998221083094","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T12:02:01Z","timestamp":1646740921000},"page":"941-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nodal Metastases in Pediatric and Adult Acinic Cell Carcinoma of the Major Salivary Glands"],"prefix":"10.1002","volume":"167","author":[{"given":"Jared C.","family":"Dublin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery NYU Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie R.","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Kansas Medical Center Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses M.","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology NYU Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Persky","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery NYU Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery NYU Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology NYU Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec E.","family":"Vaezi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery NYU Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc G.T.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery Head and Neck Service Memorial Sloan\u2010Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Givi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery NYU Langone Health New York New York 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