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Clinical practice guidelines, systematic reviews, and randomized controlled trials, when available, were preferentially retrieved. Interventions and outcomes of SCS use were compiled to generate summary tables and narrative synthesis of findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Evidence on the effectiveness of SCS varies widely across otolaryngology disorders. High\u2010level evidence supports SCS use for Bell's palsy, sinonasal polyposis, and lower airway disease. Conversely, evidence is weak or absent for upper respiratory tract infection, eustachian tube dysfunction, benign paroxysmal positional vertigo, adenotonsillar hypertrophy, or nonallergic rhinitis. Evidence is indeterminate for acute laryngitis, acute pharyngitis, acute sinusitis, angioedema, chronic rhinosinusitis without polyps, M\u00e9ni\u00e8re's disease, postviral olfactory loss, postoperative nerve paresis\/paralysis, facial pain, and sudden sensorineural hearing loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications for Practice<\/jats:title><jats:p>Clinicians should bring an evidence\u2010informed lens to SCS prescribing to best counsel patients regarding the risks, anticipated benefits, and limited data on long\u2010term effects. Alternate routes of corticosteroid administration\u2014such as sprays, drops, inhalers, and intralesional injections\u2014may be preferable for many disorders, particularly those that are self\u2010limited or require a prolonged duration of therapy. Prudent use of SCS reduces the risk of medication\u2010related adverse effects. Clinicians who are conversant with high\u2010level evidence can achieve optimal outcomes and stewardship when prescribing SCS.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998221087664","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T12:04:01Z","timestamp":1648555441000},"page":"643-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Systemic Steroids for Otolaryngology\u2013Head and Neck Surgery Disorders: An Evidence\u2010Based Primer for Clinicians"],"prefix":"10.1002","volume":"168","author":[{"given":"Edward D.","family":"McCoul","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Ochsner Clinic  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uchechukwu C.","family":"Megwalu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, School of Medicine Stanford University  Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Joe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth H.","family":"Ference","sequence":"additional","affiliation":[{"name":"Caruso Department of Otolaryngology\u2013Head and Neck Surgery Keck School of Medicine of the University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prayag S.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Figueroa\u2010Morales","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mexican Social Security Institute  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Massachusetts Eye and Ear Infirmary and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"issue":"4","key":"e_1_2_21_2_1","first-page":"343","article-title":"Short\u2010term corticosteroids and avascular necrosis: medical and legal realities","volume":"80","author":"Richards RN","year":"2007","journal-title":"Cutis"},{"key":"e_1_2_21_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810390470"},{"key":"e_1_2_21_4_1","article-title":"Medicolegal considerations regarding steroid use in otolaryngology: a review of the literature","author":"Young K","year":"2021","journal-title":"Annals Otol Rhinol Laryngol"},{"key":"e_1_2_21_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21016"},{"key":"e_1_2_21_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4223"},{"key":"e_1_2_21_7_1","first-page":"376","article-title":"Informed consent and its documentation: implications for medical malpractice liability","volume":"55","author":"Karim Z","year":"2013","journal-title":"BC Med J"},{"key":"e_1_2_21_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.04.003"},{"key":"e_1_2_21_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201904-0903SO"},{"key":"e_1_2_21_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.07.046"},{"key":"e_1_2_21_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S176026"},{"key":"e_1_2_21_12_1","unstructured":"UpToDate.Comparison of systemic glucocorticoid preparations. 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