{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:22:39Z","timestamp":1781302959886,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine demographic factors and clinicopathologic characteristics associated with survival in young patients (age &lt;45 years) with early\u2010 (I\u2010II) or late\u2010stage (III\u2010IV) oral tongue squamous cell carcinoma (OTSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective database review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>National Cancer Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of 3262 OTSCC cases in young patients between 2005 and 2014 was performed by using data from the National Cancer Database. Factors affecting 2\u2010year survival in patients with early\u2010 and late\u2010stage disease were evaluated via univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1899 patients with early\u2010stage OTSCC and 1363 with late\u2010stage OTSCC were analyzed. In multivariate analysis of early\u2010stage OTSCC, high tumor grade (hazard ratio, 2.08 [95% CI, 1.45\u20102.99]), local metastasis (2.85 [1.37\u20105.95]), and tumor size (1.04 [1.02\u20101.07]) were predictors of mortality. In late\u2010stage OTSCC, African American race (2.79 [1.40\u20105.56]), positive surgical margins (1.77 [1.07\u20102.93]), local metastasis (2.20 [1.03\u20104.72]), distant metastasis (11.66 [2.10\u201064.73]), depth of invasion (1.03 [1.01\u20101.05]), and tumor size (1.01 [1.003\u20101.01]) were predictors of mortality. Subset analysis of clinical N0\u2010stage tumors revealed that treatment with surgery alone was associated with improved survival (<jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Positive lymph nodes, high tumor grade, and larger tumor size were associated with increased mortality risk in early\u2010 and late\u2010stage young OTSCC. More aggressive up\u2010front treatment, including extirpative surgery and elective neck dissection, may be associated with improved outcomes and should be considered in early\u2010stage cases with high\u2010risk features.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998221101191","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T12:37:21Z","timestamp":1655210241000},"page":"398-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Stage\u2010Specific Survival in Young Patients With Oral Tongue Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"168","author":[{"given":"Krishna K.","family":"Bommakanti","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at UCLA  Los Angeles California 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