{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:48:22Z","timestamp":1760986102547,"version":"build-2065373602"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 109-2511-H-567-001-MY2"],"award-info":[{"award-number":["MOST 109-2511-H-567-001-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2511-H-567-001-MY2"],"award-info":[{"award-number":["MOST 110-2511-H-567-001-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-B-111018"],"award-info":[{"award-number":["TSGH-B-111018"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009974","name":"Cardinal Tien Hospital","doi-asserted-by":"publisher","award":["CTH111A-2203"],"award-info":[{"award-number":["CTH111A-2203"]}],"id":[{"id":"10.13039\/501100009974","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cardinal Tien Junior College of Healthcare and Management","award":["CTCN-109C-09"],"award-info":[{"award-number":["CTCN-109C-09"]}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the risk of injury in patients with M\u00e9ni\u00e8re's disease (MD) and the effects of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Population\u2010based retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Data were collected from the Longitudinal Health Insurance Database 2005, containing the information of 2 million randomly selected individuals in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 90,481 patients with newly diagnosed MD between 2000 and 2017 and 361,924 matched individuals without MD. The study outcomes were diagnoses of all\u2010cause injuries. The Kaplan\u2010Meier method was used to determine the cumulative incidence rates of injury in the MD and non\u2010MD cohorts, and a log\u2010rank test was used to analyze the differences between the cohorts. Cox proportional hazards models were used to calculate the 18\u2010year hazard ratios of each cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 80,151 patients were diagnosed with injuries during the follow\u2010up period: 24,031 and 56,120 from the MD and non\u2010MD cohorts, respectively. The adjusted hazard ratio (aHR) was 2.19 (95% CI, 2.16\u20102.35) after adjusting for demographic characteristics and comorbidities. Subgroup analysis revealed that MD was associated with an increased incidence of unintentional and intentional injuries (aHR, 2.24 [95% CI, 2.21\u20102.41] and 2.05 [95% CI, 2.01\u20102.19], respectively). Treatment with diuretics, antivertigo medications, or surgery did not reduce the risk of injury (aHR, 0.98 [95% CI, 0.59\u20101.54], 0.94 [95% CI, 0.58\u20101.50], and 0.99 [95% CI, 0.61\u20101.54]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MD is independently associated with an increased risk of injuries. Medical or surgical treatment for MD does not reduce the risk of injury in patients with MD. Physicians should counsel patients with MD regarding preventive measures for avoiding subsequent injuries.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998221106628","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T16:01:50Z","timestamp":1656432110000},"page":"443-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased Risk of Injury in M\u00e9ni\u00e8re's Disease and Effects of Treatment: Population\u2010Based Retrospective Cohort Study"],"prefix":"10.1002","volume":"168","author":[{"given":"Po\u2010Ling","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medical Education and Research Cardinal Tien Hospital  New Taipei City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Che","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences National Defense Medical Center  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