{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:51:49Z","timestamp":1792889509339,"version":"4.5.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify the rates and types of postoperative complications in patients with and without Graves\u2019 disease undergoing total thyroidectomy using the National Surgical Quality Improvement Program (NSQIP) database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>All hospitals participating in NSQIP from 2007 to 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thyroidectomy data were abstracted from the NSQIP database from 2007 to 2017 using related <jats:italic>Current Procedural Terminology<\/jats:italic> codes. Exclusion criteria included diagnosis of malignancy and partial thyroidectomy. Patients with a diagnosis of Graves\u2019 disease were compared against the control group, which consisted of other nononcologic diagnoses. Statistical analysis including matched pair analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Unmatched data demonstrated that patients with Graves\u2019 disease who underwent total thyroidectomy (n = 5495) had a higher rate of readmission (odds ratio [OR], 1.41; 95% CI, 1.16\u20101.73) and rate of reoperation (OR, 2.29; 95% CI, 1.88\u20102.79) in comparison to control patients (n = 24,213). They also had a higher rate of postoperative complication (OR, 1.54; 95% CI, 1.23\u20101.93) especially for wound\u2010related outcomes (OR, 1.88; 95% CI, 1.32\u20102.69), readmission for postoperative hypocalcemia (OR, 2.12; 95% CI, 1.54\u20102.92), and reoperation for hematoma or hemorrhage (OR, 1.88; 95% CI, 1.32\u20102.69). A matched\u2010pair analysis of the data also demonstrated similar significant results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with Graves\u2019 disease undergoing total thyroidectomy are at higher risk of complications in comparison to those who do not have Graves\u2019 disease, likely due to sequelae of the disease. However, overall rates were low, suggesting that the procedure remains relatively low risk and should continue to be offered to select patients who meet criteria for surgery.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998221108050","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T16:02:23Z","timestamp":1656432143000},"page":"754-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Postoperative Complications After Total Thyroidectomy for Patients With Graves\u2019 Disease"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-7899","authenticated-orcid":false,"given":"Jennifer J.","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology SUNY Downstate School of Medicine  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Irizarry","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology SUNY Downstate School of Medicine  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lousette Saint","family":"Victor","sequence":"additional","affiliation":[{"name":"SUNY Downstate School of Public Health  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Hoepner","sequence":"additional","affiliation":[{"name":"SUNY Downstate School of Public Health  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya","family":"Chernichenko","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology SUNY Downstate School of Medicine  Brooklyn New York USA"},{"name":"New York Presbyterian Brooklyn Methodist Hospital  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0229"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14073-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.041202"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2019.100183"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0500"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005752"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v042.i08"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cali.2017.10.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003725"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.7.920"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.14.1606"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/01945998221108050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/01945998221108050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/01945998221108050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:43:06Z","timestamp":1760960586000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/01945998221108050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,28]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1177\/01945998221108050"],"URL":"https:\/\/doi.org\/10.1177\/01945998221108050","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,28]]},"assertion":[{"value":"2022-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}