{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:41:33Z","timestamp":1776271293795,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171129"],"award-info":[{"award-number":["82171129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"publisher","award":["RC (GG) 201707"],"award-info":[{"award-number":["RC (GG) 201707"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010229","name":"Natural Science Foundation of Tianjin Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["XZ2019ZR-ZY72 (Z)"],"award-info":[{"award-number":["XZ2019ZR-ZY72 (Z)"]}],"id":[{"id":"10.13039\/501100010229","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Key research and development plan of Shaanxi Province","award":["2021SF-286"],"award-info":[{"award-number":["2021SF-286"]}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to analyze the characteristics of laryngopharyngeal reflux (LPR) by using narrow band imaging (NBI) endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A large\u2010volume practice with tertiary care providers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 67 patients with suspected LPR who underwent 24\u2010hour multichannel intraluminal impedance\u2013pH monitoring were included from June 2020 to March 2022. Manifestations of NBI endoscopy included submucosal clustered brownish microvessels (CBMs), spotted brownish microvessels, and no special microvessels; the latter 2 formed the non\u2010CBM group. The manifestations of all patients and their changes were observed after 8 weeks of proton pump inhibitor and symptomatic treatment for patients with LPR, and symptomatic treatment for patients without LPR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the results of 24\u2010hour multichannel intraluminal impedance\u2013pH monitoring, the incidence of submucosal CBMs was significantly higher in patients with LPR (30 cases) than in those without LPR (37 cases, <jats:italic>P<\/jats:italic> &lt; .001), particularly in the posterior cricoid area (<jats:italic>P<\/jats:italic> &lt; .001). Besides Reflux Finding Score, the incidence of signs such as subglottic edema and vocal fold edema was significantly higher in the CBM group than the non\u2010CBM group (<jats:italic>P<\/jats:italic> &lt; .05). Finally, 22 patients with LPR (91.7%) and only 2 patients without LPR (28.6%) underwent a transformation from CBMs to spotted brownish microvessels after continuous medication for 8 weeks in the CBM group (\u03c7<jats:sup>2<\/jats:sup> = 15.916, <jats:italic>P<\/jats:italic> &lt; .001), while no significant change was observed in patients with or without LPR in the non\u2010CBM group (<jats:italic>P<\/jats:italic> &gt; .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Submucosal CBMs in the posterior cricoid area under NBI endoscopy may be a characteristic of LPR.<\/jats:p><jats:p>Level of Evidence: 4.<\/jats:p><\/jats:sec>","DOI":"10.1177\/01945998221109220","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T12:01:13Z","timestamp":1657022473000},"page":"790-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Submucosal Clustered Brownish Microvessels Based on NBI Endoscopy: A Characteristic of LPR"],"prefix":"10.1002","volume":"168","author":[{"given":"Meng","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing\u2010Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2706-7817","authenticated-orcid":false,"given":"Xiao\u2010Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an 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