{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:01:26Z","timestamp":1791669686484,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Voice prosthesis leakage significantly affects the quality of life of patients undergoing laryngectomy, causing insecurity and frequent unplanned hospital visits and costs. In this study, the concept of prophylactic voice prosthesis replacement was explored to prevent leakages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included all patients who underwent laryngectomy between 2000 and 2012 in the Netherlands Cancer Institute. Device lifetimes and voice prosthesis replacements of a retrospective cohort were used to calculate the number of needed voice prostheses per patient per year to prevent 70% of the leakages by prophylactic replacement. Various strategies for the timing of prophylactic replacement were considered: adaptive strategies based on the individual patient's history of replacement and fixed strategies based on the results of patients with similar voice prosthesis or treatment characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients used a median 3.4 voice prostheses per year (range, 0.1\u201048.1). We found high inter\u2010 and intrapatient variability in device lifetime. When prophylactic replacement is applied, this would become a median 9.4 voice prostheses per year, which means replacement every 38 days, implying &gt;6 additional voice prostheses per patient per year. The individual adaptive model showed that preventing 70% of the leakages was impossible for most patients and only a median 25% can be prevented. Monte\u2010Carlo simulations showed that prophylactic replacement is not feasible due to the high coefficient of variation (SD\/mean) in device lifetime.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on our simulations, prophylactic replacement of voice prostheses is not feasible due to high inter\u2010 and intrapatient variation in device lifetime.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/01945998221116815","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T12:00:46Z","timestamp":1659441646000},"page":"429-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Does Prophylactic Replacement of Voice Prosthesis Make Sense? A Study to Predict Prosthesis Lifetime"],"prefix":"10.1002","volume":"168","author":[{"given":"Anne N.","family":"Heirman","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"van der Noort","sequence":"additional","affiliation":[{"name":"Department of Biometrics and Statistics The Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"van Son","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute  Amsterdam the Netherlands"},{"name":"Amsterdam Center of Language and Communication University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Japke F.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette","family":"van der Molen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyorgy B.","family":"Halmos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, University of Groningen University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Dirven","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel W.M.","family":"van den Brekel","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute  Amsterdam the Netherlands"},{"name":"Amsterdam Center of Language and Communication University of Amsterdam  Amsterdam the Netherlands"},{"name":"Department of Maxillofacial Surgery Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4790-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.2771"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25364"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318159ebde"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810395362"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3402497"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20764"},{"key":"e_1_2_8_9_1","article-title":"Periprosthetic leakage in tracheoesophageal prosthesis: proposal of a standardized therapeutic algorithm","author":"Parrilla C","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000361"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ancard.2004.11.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.11.1320"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-925292"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310015371"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-017-0700-z"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2611-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.2771"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2015173"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13141"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24014"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21399"},{"key":"e_1_2_8_23_1","unstructured":"RzepakowskaA.Estimation of benefit from regular versus leakage\u2010related exchange of voice prosthesis in patients post laryngectomy considering complications rate fistula colonization byCandidaspecies and patients satisfaction feedback.ClinicalTrials.gov.2020. 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