{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:30:15Z","timestamp":1771461015867,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":13871,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1978,5]]},"abstract":"<jats:p>Amyotrophic lateral sclerosis is a progressive degenerative neuromuscular disease of insidious onset. It involves upper and lower motor neurons and causes both spastic and atrophic muscular symptoms. More than one fourth of patients have complaints relating to the head and neck (bulbar palsy); thus, the otolaryngologist may be the first physician to see them. Predominant symptoms are slurred speech, hoarseness, dysphagia, and dyspnea. Muscular weakness, atrophy, and fasciculation are noted on examination. The course is relentless, and only 20% of patients survive five years after diagnosis.<\/jats:p>","DOI":"10.1177\/019459987808600319","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T12:40:03Z","timestamp":1461242403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The Otolaryngologic Presentation of Amyotrophic Lateral Sclerosis"],"prefix":"10.1002","volume":"86","author":[{"suffix":"III","given":"Robert J.","family":"Carpenter","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Frank M.","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"399","volume-title":"Lectures on the Disease of the Nervous System","author":"Charcot JM","year":"1881"},{"key":"e_1_2_1_3_1","first-page":"622","volume-title":"De l'atrophic musculaire avec transformation groisseuse, De l'electrisation localisee","author":"Guillaume BA","year":"1855"},{"key":"e_1_2_1_4_1","first-page":"5","article-title":"Recherches sur une malodic non encore dearite du systeme musculaire (atrophic musculaire progressive)","volume":"24","author":"Aran FA","year":"1850","journal-title":"Arch Gen Med"},{"key":"e_1_2_1_5_1","first-page":"283","article-title":"Paralysie musculaire progressive de la langue de voile du palais et des leures","volume":"16","author":"Guillaume BA","year":"1860","journal-title":"Arch Gen Med"},{"key":"e_1_2_1_6_1","first-page":"438","article-title":"Esophageal motility in amyotrophic lateral sclerosis","volume":"32","author":"Smith AN","year":"1957","journal-title":"Proc Staff Meeting of the Mayo Clinic"},{"key":"e_1_2_1_7_1","first-page":"441","article-title":"Electromyographic studies in amyotrophic lateral sclerosis","volume":"32","author":"Lambert EH","year":"1957","journal-title":"Proc Staff Meeting of the Mayo Clinic"},{"key":"e_1_2_1_8_1","first-page":"537","article-title":"Patient resistance and prognosis in amyotrophic lateral sclerosis","volume":"51","author":"Mulder DW","year":"1976","journal-title":"Mayo Clinic Proc"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019459987808600319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459987808600319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:04:30Z","timestamp":1760969070000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459987808600319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,5]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,5]]}},"alternative-id":["10.1177\/019459987808600319"],"URL":"https:\/\/doi.org\/10.1177\/019459987808600319","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,5]]},"assertion":[{"value":"2016-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}