{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:45:55Z","timestamp":1761007555706,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":13748,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1978,9]]},"abstract":"<jats:p>A lethal case of rhino\u2010orbital\u2010cerebral phycomycosis (mucormycosis) in an otherwise healthy man is presented. The clinical, radiologic, and ante mortem surgical pathology associated with microbiologic examinations failed to yield the diagnosis of fungal infection as the cause of a clinical presentation of acute sphenoid sinusitis with a fulminant cavernous sinus thrombosis. No similar case report was found in review of the literature. There is a need for a high degree of suspicion in this condition to improve the uniformly poor prognosis in this devastating infectious disease. Emphasis is placed on the necessity for early tissue or microbiologic diagnosis with appropriate histologic stains and fungal cultures. Treatment consists of extensive surgical excision of all necrotic or questionably viable tissue in conjunction with alternate\u2010day amphotericin B therapy.<\/jats:p>","DOI":"10.1177\/019459987808600505","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T12:08:12Z","timestamp":1460981292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Lethal Rhinocerebral Phycomycosis in a Healthy Adult: A Case Report and Review of the Literature"],"prefix":"10.1002","volume":"86","author":[{"given":"John B.","family":"Castelli","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Naval Aerospace and Regional Medical Center Pensacola Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Pallin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The Medical Center Clinic Pensacola Florida"},{"name":"Louisiana State University Medical Center New Orleans"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947007900107"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)90503-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5280.766"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(69)90994-5"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-66-4-735"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1961.01840020228012"},{"key":"e_1_2_1_8_1","first-page":"1","article-title":"Cerebral mucormycosis (phycomycosis): Ocular findings and review of literature","volume":"6","author":"Ferry AP","year":"1961","journal-title":"Surv Ophthalmol"},{"key":"e_1_2_1_9_1","first-page":"963","article-title":"Phycomycosis: A clinicopathologic study of 51 cases","volume":"11","author":"Straatsma MR","year":"1962","journal-title":"Lab Invest"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-68-1-122"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195903\/04)12:2<330::AID-CNCR2820120217>3.0.CO;2-F"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(67)91560-7"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/115.1.113"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197703000-00007"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019459987808600505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459987808600505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:57:16Z","timestamp":1760968636000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459987808600505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,9]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,9]]}},"alternative-id":["10.1177\/019459987808600505"],"URL":"https:\/\/doi.org\/10.1177\/019459987808600505","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1978,9]]},"assertion":[{"value":"2016-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}