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In view of the paucity of information on the role of vitamin A in the inner ear, three experiments were performed to examine this relationship.<\/jats:p><jats:p>Temporal bone histopathology was studied in rats deprived of vitamin A. In a second experiment, vitamin A\u2010deficient rats were maintained with vitamin A acid and the histopathology was studied under the light microscope. In the third experiment, a microfluorometric estimate of the content of vitamin A in the guinea pig cochlea was performed. A fluorescent compound with the exact spectral characteristics of vitamin A was found in the guinea pig cochlea at a concentration of 21.2\u03bcg\/gm, which is ten times the vitamin A concentration found in most other tissues.<\/jats:p>","DOI":"10.1177\/01945998780860s411","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T12:39:36Z","timestamp":1461242376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Experimental Studies on the Role of Vitamin a in the Inner Ear"],"prefix":"10.1002","volume":"86","author":[{"given":"Richard A.","family":"Chole","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology University of California Davis California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1965.030.01.031"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/9.4.23"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.162.3850.230"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-108-27066"},{"key":"e_1_2_1_6_1","first-page":"362","article-title":"The reversible effect of vitamin A deficiency on taste","volume":"21","author":"Bernard RA","year":"1962","journal-title":"Fed Proc"},{"key":"e_1_2_1_7_1","first-page":"410","article-title":"The taste bud membrane and the role of vitamin A","volume":"34","author":"Duncan CJ","year":"1964","journal-title":"Int Z Vitaminforsch"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1962.00740040122008"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1938.sp003688"},{"key":"e_1_2_1_10_1","unstructured":"HumeEM KrebsHA:Vitamin A Requirement of Human Adults\u2014An Experimental Study of Vitamin A Deprivation in Man Series 264 London Medical Research Council Special Report 1949."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/119.4-5.432"},{"issue":"38","key":"e_1_2_1_12_1","article-title":"Heredopathia atactica polyneuritiformis: A familial syndrome not hitherto described","author":"Refsum S","year":"1914","journal-title":"Acta Psychiatr, ET Neurol"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.11.61.1"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-194007000-00003"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0055370"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348944105000204"},{"key":"e_1_2_1_17_1","first-page":"177","article-title":"Avitaminosi \u201cA\u201d sperimentale ed orecchio","volume":"61","author":"Lovino M","year":"1950","journal-title":"Arch Hal Otol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1951.03750050035003"},{"key":"e_1_2_1_19_1","first-page":"75","article-title":"Observations in the therapy of deafness and tinnitus with parenteral vitamin A in massive doses","volume":"29","author":"Anderson JR","year":"1950","journal-title":"Eye Ear Nose Throat Mon"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195106000-00007"},{"key":"e_1_2_1_21_1","first-page":"1555","article-title":"Tinnitus and vitamin A. 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