{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:13:55Z","timestamp":1776748435174,"version":"3.51.2"},"reference-count":4,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":13140,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1980,5]]},"abstract":"<jats:p>Chronic otitis externa may be a sensitivity (dermatophyte) reaction from a distant pathogenic superficial fungal infection, eg, tinea pedis and monilial vaginitis, which are often difficult to eradicate. Skin testing is done with a combined antigenic extract of TOE <jats:italic>(Trichophyton; Oidiomycetes<\/jats:italic>, ie, <jats:italic>Monilia<\/jats:italic> or <jats:italic>Candida albicans<\/jats:italic>; and <jats:italic>Epidermophyton<\/jats:italic>). The serial dilution titration method of skin testing is done, and the end point of reaction is determined. Treatment is begun on a weekly basis, with subcutaneous administration of 0.3 cc of a TOE extract two dilutions weaker than the end point Symptomatic improvement is usually noted within two to four weeks, with objective improvement within eight weeks. After a variable maintenance period, the injections are spaced at less frequent intervals.<\/jats:p>","DOI":"10.1177\/019459988008800318","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T21:34:12Z","timestamp":1460151252000},"page":"293-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment of Chronic Otitis Externa with <i>Trichophyton, Oidiomycetes, Epidermophyton<\/i> Antigen"],"prefix":"10.1002","volume":"88","author":[{"given":"Gary D.","family":"Becker","sequence":"first","affiliation":[{"name":"Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"225","article-title":"Treatment of chronic external otitis","volume":"19","author":"Brown DW","year":"1979","journal-title":"Trans Am Soc Ophthalmol Otolaryngol Allergy"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1959.00730040600009"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)32814-0"},{"key":"e_1_2_1_5_1","first-page":"660","volume-title":"Dermatology","author":"Moschella SL","year":"1975"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988008800318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988008800318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:44:47Z","timestamp":1760967887000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988008800318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,5]]},"references-count":4,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1980,5]]}},"alternative-id":["10.1177\/019459988008800318"],"URL":"https:\/\/doi.org\/10.1177\/019459988008800318","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,5]]},"assertion":[{"value":"2016-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}