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Permanent perforation occurred in 25% (17\/68 ears). Use of large\u2010bore tubes proved effective and continues to be indicated in certain conditions of chronic otitis media that are refractory to other forms of treatment.<\/jats:p>","DOI":"10.1177\/019459988008800511","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T21:37:35Z","timestamp":1460151455000},"page":"581-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects of Large\u2010Bore Middle Ear Ventilation Tubes"],"prefix":"10.1002","volume":"88","author":[{"given":"James J.","family":"Holt","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G.","family":"Harner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","article-title":"On the structure and uses of the membrana tympani of the ear","author":"Home E","year":"1800","journal-title":"Philos Trans R Soc Lond"},{"key":"e_1_2_1_3_1","first-page":"151","article-title":"Observations on the effects which take place from the destruction of the membrana tympani of the ear","author":"Cooper A","year":"1800","journal-title":"Philos Trans R Soc Lond"},{"key":"e_1_2_1_4_1","first-page":"435","article-title":"Farther observations on the effects which take place from the destruction of the membrana tympani of the ear: With an account of an operation for the removal of a particular species of deafness","author":"Cooper A","year":"1801","journal-title":"Philos Trans R Soc Lond"},{"key":"e_1_2_1_5_1","first-page":"216","volume-title":"The Diseases of the Ear: Their Nature, Diagnosis, and Treatment","author":"Toynbee J","year":"1868"},{"key":"e_1_2_1_6_1","first-page":"318","volume-title":"Politzer's Text\u2010Book of the Diseases of the Ear for Students and Practitioners","author":"Ballin MJ","year":"1926"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1954.00710050665001"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1964.00750040485018"},{"key":"e_1_2_1_9_1","first-page":"640","article-title":"Malleus clip tube for long\u2010term equalization of middle ear pressure","volume":"70","author":"Silverstein H","year":"1966","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1288\/lary.1967.000770408"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196904000-00003"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1977.87.11.1833"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197307000-00002"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1974.00780040157015"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780090040002"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988008800511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988008800511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:58:35Z","timestamp":1760957915000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988008800511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,9]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1980,9]]}},"alternative-id":["10.1177\/019459988008800511"],"URL":"https:\/\/doi.org\/10.1177\/019459988008800511","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1980,9]]},"assertion":[{"value":"2016-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}