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All three treatment methods appeared equally effective in irradicating stage I and II disease. Stage III floor\u2010of\u2010mouth epidermoid carcinoma was similarly controlled by either surgical therapy or combined therapy. Irradiation therapy alone was markedly inferior in treatment of stage III disease. Stage IV disease was poorly handled by any of the treatment methods. Histologic factors, tumor characteristics, tumor spread, nodal status, and staging did not appear in the majority of cases to significantly influence treatment selection or survival or both.<\/jats:p>","DOI":"10.1177\/019459988008800616","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T21:38:08Z","timestamp":1460151488000},"page":"714-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Epidermoid Carcinoma of the Floor of the Mouth: Surgical Therapy vs Combined Therapy VS Radiation Therapy"],"prefix":"10.1002","volume":"88","author":[{"given":"William R.","family":"Panje","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Maxillofacial Surgery University Hospitals Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Smith","sequence":"additional","affiliation":[{"name":"Fort Collins Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian F.","family":"McCabe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Maxillofacial Surgery University Hospitals Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(75)90490-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780170034002"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1977.87.11.1904"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197904000-00007"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.102.1.176"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100405"},{"key":"e_1_2_1_8_1","article-title":"Combined therapy in the treatment of epidermoid carcinoma of the tonsil","author":"Roberts DM","year":"1979","journal-title":"Am J Surg"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946807700313"},{"key":"e_1_2_1_10_1","first-page":"78","volume-title":"Statistical Analysis: A Computer Oriented Approach","author":"Afifi AA","year":"1972"},{"key":"e_1_2_1_11_1","first-page":"243","volume-title":"Introduction to Statistical Analysis","author":"Dixon WJ","year":"1969"},{"volume-title":"Clinical Staging System for Carcinoma of the Oral Cavity","year":"1977","key":"e_1_2_1_12_1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196907000-00008"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(71)90473-9"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1971.00770060418010"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197010000-00005"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(73)80033-9"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988008800616","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988008800616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:41:06Z","timestamp":1760964066000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988008800616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1980,11]]}},"alternative-id":["10.1177\/019459988008800616"],"URL":"https:\/\/doi.org\/10.1177\/019459988008800616","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1980,11]]},"assertion":[{"value":"2016-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}