{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:33:35Z","timestamp":1761006815948,"version":"build-2065373602"},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,11]],"date-time":"2016-12-11T00:00:00Z","timestamp":1481414400000},"content-version":"vor","delay-in-days":13069,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1981,3]]},"abstract":"<jats:p>Recurrent epistaxis is usually the main symptom found in patients with hereditary hemorrhagic telangiectasia (HHT)\u2014Osler Rendu Weber syndrome. Therapies have included intranasal cautery, septal dermoplasty, intra\u2010arterial embolization, and arterial ligation. These procedures have met with limited success. Laser photocoagulation has achieved early success in the gastrointestinal (GI) telangiectatic lesions.<\/jats:p><jats:p>In this report, cutaneous and intranasal lesions of eight HHT patients have been treated with laser photocoagulation using a flexible fiber delivery system connected to 3\u00a0W argon and 55\u00a0W neodymium:yttrium\u2010aluminum\u2010garnet (Nd:YAG) laser sources. The patients noted a great reduction in the frequency and severity of epistaxis, reduction in the need for blood transfusion, and reduction in iron therapy necessary to maintain adequate hemoglobin levels. Previously, five of these patients were considered treatment failures after extensive surgical therapy. No serious complications have been encountered.<\/jats:p><jats:p>Laser photocoagulation of HHT patients appears to be a promising therapeutic advance. The progressive nature of HHT necessitates close follow\u2010up and retreatment of new lesions as they appear.<\/jats:p>","DOI":"10.1177\/019459988108900212","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T15:14:03Z","timestamp":1483629243000},"page":"204-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Laser Photocoagulation in Hereditary Hemorrhagic Telangiectasia"],"prefix":"10.1002","volume":"89","author":[{"given":"James L.","family":"Parkin","sequence":"first","affiliation":[{"name":"Division of Otolaryngology Department of Surgery College of Medicine University of Utah Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Department of Surgery College of Medicine University of Utah Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"352","volume-title":"Syndromes of the Head and Neck","author":"Gorlin RJ","year":"1976"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900010104"},{"key":"e_1_2_1_4_1","first-page":"178","volume-title":"Laser Surgery","author":"Icheta F","year":"1975"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000399583"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(79)90215-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(78)90069-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900010108"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988108900212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988108900212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:22:52Z","timestamp":1760955772000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988108900212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,3]]}},"alternative-id":["10.1177\/019459988108900212"],"URL":"https:\/\/doi.org\/10.1177\/019459988108900212","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1981,3]]},"assertion":[{"value":"2016-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}