{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:19:37Z","timestamp":1767665977807,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,11]],"date-time":"2016-12-11T00:00:00Z","timestamp":1481414400000},"content-version":"vor","delay-in-days":12947,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1981,7]]},"abstract":"<jats:p>Element analysis of microareas of otospongiotic specimens is described. A total of 36 otospongiotic stapes are ultrasectioned without decalcification and examined using a transmission and a scanning electron microscope (STEM\u2010mode). The latter was equipped with an energy dispersive x\u2010ray analyzer. Twenty of the stapes came from patients who have had sodium fluoride (NaF) treatment (15 to 45\u00a0mg\/day) for a minimum of 12\u00a0months. The otospongiotic stapes are classified as spongiotic and sclerotic according to their pathologic characteristics and state of mineralization. Using the Ca\/P ratio as criterion\u2014measured by the characteristic x\u2010ray fluorescence\u2014it was shown in a blind study that the NaF\u2010treated otospongiotic stapes had a statistically higher Ca\/P ratio, indicating that the fluoride may stabilize otospongiotic lesions, particularly the spongiotic type with unstable mineralization.<\/jats:p>","DOI":"10.1177\/019459988108900425","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T15:19:47Z","timestamp":1483629587000},"page":"646-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Otospongiosis: Morphologic and Microchemical Investigation after Naf\u2010Treatment"],"prefix":"10.1002","volume":"89","author":[{"given":"Paul","family":"Bretlau","sequence":"first","affiliation":[{"name":"University ENT Department Gentofte Hospital, Copenhagen Institute for Historical Geology and Palaeontology Copenhagen University Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J\u00f8rgen","family":"Hansen","sequence":"additional","affiliation":[{"name":"University ENT Department Gentofte Hospital, Copenhagen Institute for Historical Geology and Palaeontology Copenhagen University Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Causse","sequence":"additional","affiliation":[{"name":"Jean Causse Clinic B\u00e9ziers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Bernard","family":"Causse","sequence":"additional","affiliation":[{"name":"Jean Causse Clinic B\u00e9ziers France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1964.00750040273006"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1966.03110180043016"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770030587011"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1966.00760020164019"},{"key":"e_1_2_1_6_1","first-page":"35","article-title":"Further experiences with moderate dosage fluoride for sensorineural hearing loss, tinnitus and vertigo due to otospongiosis","volume":"22","author":"Shambaugh GE","year":"1977","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_1_7_1","unstructured":"PetrovicA StuzmannJ:Effects of sodium fluoride in osteoformation mineralisation and osteoresorption in otospongiotic and meatal bone: A histomorphometric study.Labyrinthine Otospongiosis. 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