{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:13:19Z","timestamp":1761293599632,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T00:00:00Z","timestamp":1476489600000},"content-version":"vor","delay-in-days":12068,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:p>We are studying membrane antigens of human squamous cell cancer with the use of naturally occurring autologous antibodies from patients\u2019 sera, along with a set of other serologic reagents and monoclonal antibodies raised against cultured squamous cell lines. Twenty\u2010eight squamous cell carcinoma cell lines have been established in our laboratory from tissues obtained from 23 patients. Antibody reactivity has been found against the autologous tumor cell line in 13 of 23 patients. One of these is of sufficient titer for detailed analysis. Four cell lines are available from this patient. UM\u2010SCC\u201017A is derived from the primary laryngeal carcinoma, and UM\u2010SCC\u201017B is derived from a lymph node metastasis removed during the same surgical procedure. Fibroblasts have been cultured from normal mucosa, and a B\u2010lymphoblastoid line has been developed by Epstein\u2010Barr virus transformation of the patient's peripheral blood lymphocytes. Antibody from this patient reacts with the UM\u2010SCC\u201017A and \u201017B tumor cell lines but does not react with the normal fibroblasts (UM\u2010NF\u201017).<\/jats:p>","DOI":"10.1177\/019459988309100503","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T12:24:49Z","timestamp":1500294289000},"page":"482-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Antibodies to human squamous cell carcinoma"],"prefix":"10.1002","volume":"91","author":[{"given":"T. E.","family":"Carey","sequence":"first","affiliation":[{"name":"The Cancer Research Laboratory Department of Otorhinolaryngology Ann Arbor Michigan"},{"name":"Department of Microbiology and Immunology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. A.","family":"Kimmel","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. R.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"The Cancer Research Laboratory Department of Otorhinolaryngology Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. E.","family":"Richter","sequence":"additional","affiliation":[{"name":"The Cancer Research Laboratory Department of Otorhinolaryngology Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Baker","sequence":"additional","affiliation":[{"name":"The Cancer Research Laboratory Department of Otorhinolaryngology Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Krause","sequence":"additional","affiliation":[{"name":"The Cancer Research Laboratory Department of Otorhinolaryngology Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,15]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197512252932607"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.9.3278"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.10.4587"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.10.5122"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.150.3.564"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1981.00790470051012"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.1.190"},{"key":"e_1_2_1_9_1","first-page":"489","article-title":"Characterization of monoclonal antibodies to human melanoma\u2010associated antigens","volume":"66","author":"Imai K","year":"1981","journal-title":"JNCI"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/256495a0"},{"key":"e_1_2_1_11_1","first-page":"341","article-title":"Cell surface antigens of human squamous cell carcinoma","volume":"78","author":"Carey TE","year":"1982","journal-title":"J Invest Dermatol"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988309100503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988309100503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:54:57Z","timestamp":1760968497000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988309100503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1983,10]]}},"alternative-id":["10.1177\/019459988309100503"],"URL":"https:\/\/doi.org\/10.1177\/019459988309100503","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1983,10]]},"assertion":[{"value":"1983-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}