{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:27:14Z","timestamp":1761744434772,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,11]],"date-time":"2016-12-11T00:00:00Z","timestamp":1481414400000},"content-version":"vor","delay-in-days":12002,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1984,2]]},"abstract":"<jats:p>Ototoxic and nephrotoxic potentiation with concomitant <jats:italic>cis<\/jats:italic>\u2010diamminedichloroplatinum, or <jats:italic>cis<\/jats:italic>\u2010platinum II (CSP), and aminoglycoside therapy was investigated in the guinea pig. We evaluated possible potentiation of the toxic effects of CSP and kanamycin compared with CSP alone in the inner ear and kidney and quantitatively localized CSP in the cochlea with gamma emission analysis of <jats:sup>195m<\/jats:sup>Pt. Kanamycin\u2010treated animals demonstrated cytocochleograms and ABR waveforms, absolute latencies, and interwave latencies for waves I, II, and III similar to control animals at our maximum level of acoustic stimulation. CSP treatment produced 60% to 70% mean outer hair cell (OHC) loss in the basal turn of the cochlea, a reduction In ABR waveform and amplitude, and an Increase in latencies of ABR waves I, II, and III. Combined CSP and kanamycin treatment produced 90% to 100% mean OHC loss in all rows of the basal turn of the cochlea, with no discernible ABR waveform corresponding to the region stimulated by a 4500 to 7000\u00a0Hz acoustic click. Combined treatment produced the most significant cortical medullary tubular necrosis and interstitial nephritis. Furthermore, this study reports for the first time localization of platinum in the inner ear.<\/jats:p>","DOI":"10.1177\/019459988409200109","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T15:13:52Z","timestamp":1483629232000},"page":"38-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Ototoxic and Nephrotoxic Effects of Combined Treatment with <i>cis<\/i>\u2010Diamminedichloroplatinum and Kanamycin in the Guinea Pig"],"prefix":"10.1002","volume":"92","author":[{"given":"Vanessa G.","family":"Schweitzer","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Kresge Hearing Research Institute Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph E.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Kresge Hearing Research Institute Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Lilly","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Kresge Hearing Research Institute Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles J.","family":"Litterst","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry and Biology National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Abrams","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Kresge Hearing Research Institute Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Christy","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Kresge Hearing Research Institute Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"191","article-title":"Clinical trials of cis\u2010diamminedichloroplatinum (NSC\u2010119875)","volume":"57","author":"Lippman AJ","year":"1973","journal-title":"Cancer Chemother Rep"},{"key":"e_1_2_1_3_1","first-page":"871","article-title":"Effects of cis\u2010diamminedichloroplatinum (NSC\u2010119875) on hearing function in man","volume":"58","author":"Piel IJ","year":"1974","journal-title":"Cancer Chemother Rep"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197704)39:4<1372::AID-CNCR2820390404>3.0.CO;2-J"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563657808988252"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930160203"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890040204"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100092355"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488209130876"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196702000-00002"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016486809120987"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/119.4-5.417"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197203000-00006"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(80)80012-3"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02103043"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00455236"},{"key":"e_1_2_1_17_1","first-page":"707","volume-title":"Handbook of sensory physiology","author":"Hawkins JE","year":"1976"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(79)80004-6"},{"key":"e_1_2_1_19_1","first-page":"5","volume-title":"Handbook of auditory and vestibular research methods","author":"Hawkins JE","year":"1976"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(77)90089-8"},{"key":"e_1_2_1_21_1","first-page":"2340","article-title":"Distribution and disposition of platinum following intravenous administration of cis\u2010dichlorodiammine platinum (II) to dogs","volume":"36","author":"Litterst CL","year":"1976","journal-title":"Cancer Res"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810301)47:5<857::AID-CNCR2820470508>3.0.CO;2-M"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(75)90098-8"},{"key":"e_1_2_1_24_1","first-page":"467","article-title":"Cis\u2010dichlorodiammineplatinum (II) (NSC\u2010119875): Hearing loss and other toxic effects in rhesus monkeys","volume":"59","author":"Stadnicki SW","year":"1975","journal-title":"Cancer Chemother Rep"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988108900424"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-95-5-628"},{"key":"e_1_2_1_27_1","first-page":"397","article-title":"Acute and chronic cisplatin nephrotoxicity in rats","volume":"44","author":"Choie DD","year":"1981","journal-title":"Lab Invest"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(81)90011-9"},{"key":"e_1_2_1_29_1","unstructured":"HillJB RussoA BlachleyJ OzolsR:Lack of nephrotoxicity of high dose cisplatin administered in hypertonic saline.(Submitted for publication 1982.)."},{"key":"e_1_2_1_30_1","unstructured":"LifschitzV HawkinsJ BakerS:Ototoxicity of cisdichlorodiammineplatinum (II) in the guinea pig and interaction with furosemide. (Unpublished data 1980.)."}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988409200109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988409200109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:02:41Z","timestamp":1760965361000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988409200109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,2]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,2]]}},"alternative-id":["10.1177\/019459988409200109"],"URL":"https:\/\/doi.org\/10.1177\/019459988409200109","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1984,2]]},"assertion":[{"value":"1983-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}