{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:45:13Z","timestamp":1761648313704,"version":"build-2065373602"},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1984,4,1]],"date-time":"1984-04-01T00:00:00Z","timestamp":449625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:p>Streptomycin sulfate has been known to be ototoxic since its use in the treatment of tuberculosis. This report describes 10 years of experience in the treatment of Meniere's disease with streptomycin. Streptomycin has been used in (1) classical Schuknecht ablation of the vestibular system in bilateral Meniere's disease; (2) classical Schuknecht ablation of the vestibular system in unilateral Meniere's disease in the only hearing ear; (3) intratympanic streptomycin in the treatment of unilateral Meniere's disease; and (4) low\u2010dose intramuscular streptomycin as outpatient treatment in unilateral Meniere's disease. The results of bilateral vestibular ablation were similar to Schuknecht's and others. Patients developed profound ataxia with a wide\u2010based gait and oscillopsia, which improved rapidly over a period of months. Approximately 30% experienced significant improvement in hearing, which usually deteriorated again after several months. All patients were relieved of vertigo. Patients with unilateral Meniere's disease in the only hearing ear responded as did the bilateral cases. Hearing in the only hearing ear was preserved in all cases. Low\u2010dose subototoxic streptomycin as outpatient treatment offers promise in some cases for relieving attacks of Meniere's disease while improving hearing without producing the temporary disabling effects of ataxia and oscillopsia. Streptomycin and similar drugs that may reduce the production of endolymph may eventually be the treatment of choice in Meniere's disease.<\/jats:p>","DOI":"10.1177\/019459988409200218","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T06:59:24Z","timestamp":1448434764000},"page":"229-232","source":"Crossref","is-referenced-by-count":22,"title":["Use of Streptomycin Sulfate in the Treatment of Meniere's Disease"],"prefix":"10.1002","volume":"92","author":[{"given":"Herbert","family":"Silverstein","sequence":"first","affiliation":[{"name":"Ear Research Foundation of Florida Sarasota Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Hyman","sequence":"additional","affiliation":[{"name":"Ear Research Foundation of Florida Sarasota Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Feldbaum","sequence":"additional","affiliation":[{"name":"Ear Research Foundation of Florida Sarasota Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Silverstein","sequence":"additional","affiliation":[{"name":"Ear Research Foundation of Florida Sarasota Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1984,4]]},"reference":[{"volume-title":"Streptomycin and dehydrostreptomycin. Antibiotics monograph No. 10","year":"1958","author":"Weinstein L.","key":"e_1_2_1_2_1"},{"key":"e_1_2_1_3_1","unstructured":"KeeferC. HewittW.:The therapeutic value of streptomycin: A study of 3000 cases.1948."},{"volume-title":"Streptomycin nature and practical applications","year":"1949","author":"Waksman S.","key":"e_1_2_1_4_1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1947.02880250027007"},{"key":"e_1_2_1_6_1","first-page":"1","article-title":"Ablation therapy in the management of Meniere's disease","volume":"132","author":"Schuknecht H.","year":"1957","journal-title":"Acta Otolaryngol Suppl (Stockh)"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","unstructured":"SingletonE. SchuknechtH.:Streptomycin sulfate in the management of Meniere's disease.Otol Clin North Am p 531.1968.","DOI":"10.1016\/S0030-6665(20)33286-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770030152010"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988409200218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988409200218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:28:33Z","timestamp":1760963313000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988409200218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,4]]}},"alternative-id":["10.1177\/019459988409200218"],"URL":"https:\/\/doi.org\/10.1177\/019459988409200218","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1984,4]]}}}