{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T21:33:21Z","timestamp":1768080801891,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1984,8,1]],"date-time":"1984-08-01T00:00:00Z","timestamp":460166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1984,8]]},"abstract":"<jats:p>Intramuscular dosages of streptomycin sulfate were titrated in eight patients with bilateral Meniere's disease in an attempt to alleviate disabling vertigo and hearing loss. It appears possible to eliminate the vertiginous episodes, preserve or improve hearing, and avoid ataxia and oscillopsia in most of these individuals. At present we consider this treatment regimen our first choice of therapy in people with bilateral active Meniere's disease or in patients whose only hearing ear is actively fluctuating and in whom associated disabling vertigo is present. Great caution and supervision should be exercised in the use of streptomycin titration therapy in the individual with bilateral Meniere's disease, as further experience is required to determine the efficacy of this form of management.<\/jats:p>","DOI":"10.1177\/019459988409200413","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T07:00:12Z","timestamp":1448434812000},"page":"440-447","source":"Crossref","is-referenced-by-count":37,"title":["Titration Streptomycin Therapy for Bilateral Meniere's Disease: A Preliminary Report"],"prefix":"10.1002","volume":"92","author":[{"given":"Malcolm D.","family":"Graham","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Michigan Medical School Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T.","family":"Sataloff","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Thomas Jefferson University Medical School Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Kemink","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Michigan Medical School Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1984,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-55-14461"},{"key":"e_1_2_1_3_1","first-page":"313","article-title":"Streptomycin in treatment of clinical tuberculosis: A preliminary report","volume":"20","author":"Hinshaw HC","year":"1945","journal-title":"Proc Staff Meet May Clin"},{"key":"e_1_2_1_4_1","first-page":"293","article-title":"Quoted in Fowler EP: Streptomycin treatment for vertigo","volume":"52","author":"Hawkins J.","year":"1948","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_1_5_1","first-page":"293","article-title":"Streptomycin treatment for vertigo","volume":"52","author":"Fowler EP","year":"1948","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348945106000311"},{"key":"e_1_2_1_7_1","first-page":"2619","article-title":"Medical treatment for Meniere's disease","volume":"31","author":"Van Deinse F.","year":"1949","journal-title":"Nederlandsch Tijschr Geneesk"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195107000-00004"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02121452"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195607000-00005"},{"key":"e_1_2_1_11_1","first-page":"14","article-title":"Ablation therapy for the relief of Meniere's disease","volume":"132","author":"Schuknecht HF","year":"1957","journal-title":"Acta Otolaryngol Suppl (Stockh)"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1967.00760040158006"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)33286-2"},{"key":"e_1_2_1_14_1","first-page":"108","article-title":"Update on the use of streptomycin therapy for Meniere's disease","volume":"2","author":"Wilson WR","year":"1980","journal-title":"Am J Otol"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988409200413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988409200413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:52:58Z","timestamp":1760968378000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988409200413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,8]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,8]]}},"alternative-id":["10.1177\/019459988409200413"],"URL":"https:\/\/doi.org\/10.1177\/019459988409200413","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,8]]}}}