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Ischemia was induced by unilateral common carotid artery ligation or temporary occlusion of both common carotid arteries, and the olfactory pathway was examined. In the olfactory pathway of the forebrain, ischemic changes were observed in the lateral olfactory tract, olfactory tubercle, olfactory ventricle, and anterior olfactory nucleus. The olfactory bulb was resistant to ischemia. Partial or complete degeneration of the ipsilateral olfactory neuroepithelium was observed in some gerbils that survived more than 14\u00a0days after the onset of ischemia. Immunohistopathologic analysis of the neuroepithelium for the olfactory marker protein revealed that functional damage of the olfactory neurons occurred in some gerbils within the first few days after the ischemic event.<\/jats:p>","DOI":"10.1177\/019459988509300109","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T09:43:54Z","timestamp":1499852634000},"page":"40-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Immunohistopathologic Analysis of Olfactory Degeneration Caused by Ischemia"],"prefix":"10.1002","volume":"93","author":[{"given":"Tadashi","family":"Nakashima","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Human Communication University of Pennsylvania School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles P.","family":"Kimmelman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Human Communication University of Pennsylvania School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James B.","family":"Snow","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Human Communication University of Pennsylvania School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(79)80010-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(80)90170-3"},{"issue":"89","key":"e_1_2_1_4_1","first-page":"1","article-title":"Degeneration and regeneration of olfactory epithelium in the mouse","volume":"91","author":"Matulionis DH","year":"1982","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01175561"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901970206"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(66)90062-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198402000-00003"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.22.5.510"},{"key":"e_1_2_1_10_1","first-page":"59","volume-title":"Proteins of the nervous system","author":"Margolis FL","year":"1980"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1975.tb03883.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/18.5.315"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.5.1221"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90703-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91023-5"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988509300109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988509300109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:55:04Z","timestamp":1760961304000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988509300109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,2]]}},"alternative-id":["10.1177\/019459988509300109"],"URL":"https:\/\/doi.org\/10.1177\/019459988509300109","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,2]]},"assertion":[{"value":"1984-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}