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The left ear was left intact. Serous effusion occurred in the attic space within 2\u00a0days after surgery, whether or not the middle ear cavity (MEC) was artificially ventilated. Between days 7 and 21 the intact\u2010ear MEC was gradually filled with effusion material that turned purulent. Effusion material did not develop in the mesotympanum and hypotympanum of the intubated ears. Microbiologic examination of the effusion material showed a microflora similar to that in the nasopharynx. Ventilation through a TT reduced the number of colonized MECs (4 vs. 10) on day 21. In the individual culture\u2010positive MEC with a TT there were fewer colonies than in the corresponding ear without a TT. These results support the contention that a TT may prevent the development of purulent otitis media.<\/jats:p>","DOI":"10.1177\/019459988509300506","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T09:24:51Z","timestamp":1499851491000},"page":"601-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tympanostomy Tubes for Prevention of Purulent Otitis Media"],"prefix":"10.1002","volume":"93","author":[{"given":"Ove","family":"S\u00f6derberg","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology University of Ume\u00e5 Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sten","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology University of Ume\u00e5 Ume\u00e5 Sweden"},{"name":"Departments of Anatomy University of Ume\u00e5 Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars\u2010Eric","family":"Stenfors","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology University of Ume\u00e5 Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Thore","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology University of Ume\u00e5 Ume\u00e5 Sweden"},{"name":"Departments of Clinical Bacteriology University of Ume\u00e5 Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_1","DOI":"10.1177\/000348948309200611"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_1","DOI":"10.1288\/00005537-198106000-00001"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_1","DOI":"10.1177\/000348948109000605"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_1","DOI":"10.1017\/S0022215100087983"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_1","DOI":"10.1177\/019459988108900228"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_1","DOI":"10.1016\/S0196-0709(82)80053-7"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_1","DOI":"10.1016\/S0165-5876(83)80113-X"},{"doi-asserted-by":"publisher","key":"e_1_2_1_9_1","DOI":"10.1016\/S0165-5876(84)80020-8"},{"doi-asserted-by":"publisher","key":"e_1_2_1_10_1","DOI":"10.1093\/infdis\/145.6.822"},{"key":"e_1_2_1_11_1","first-page":"110","volume-title":"BBL manual of products and laboratory procedures","author":"Rohde PA","year":"1968"},{"key":"e_1_2_1_12_1","first-page":"287","article-title":"Mast cells in the pars flaccida of the tympanic membrane. 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