{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T15:11:55Z","timestamp":1760973115932,"version":"build-2065373602"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":10944,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:p>This historically controlled study evaluates radiation therapy in 119 patients\u2014with squamous cell carcinomas of the head and neck\u2014who underwent surgery alone (SA) or surgery plus radiation (S + R). The primary tumor control and nodal control, in patients with negative surgical margins who had surgery alone (SA), were 63% in the oral cavity, 60% in the oropharynx, and 67% in the hypopharynx. The same rates for S + R group and negative surgical margins were 100%, 73%, and 100%. Combining the patients with negative and positive surgical margins, control of the tumor and noddl control were the same in the oral cavity for both treatment groups (41% for SA and 44% for S + R) and increased with the addition of radiation in the oropharynx (30% for SA to 65% for S + R) and hypopharynx (33% for SA to 86% for S + R), in spite of higher percentages of T<jats:sup>3<\/jats:sup> and T<jats:sup>4<\/jats:sup> tumor and positive lymph nodes in the S + R group. The lower control rote in patients who had surgery alone could be due (in part) to inadequate surgery at the primary site (42% local excision) and lack of neck dissection (35% for SA vs. 77% for S + R). Postoperative radiation therapy to the primary site and neck is shown to effectively reduce local recurrence in patients with oral cavity and oropharynx cancer, regardless of surgical margins.<\/jats:p>","DOI":"10.1177\/019459988609400612","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T09:31:49Z","timestamp":1499851909000},"page":"601-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Value of Radiation Therapy in Addition to Surgery for Cancer of the Head and Neck"],"prefix":"10.1002","volume":"94","author":[{"given":"Ahmad","family":"Sadeghi","sequence":"first","affiliation":[{"name":"West Los Angeles VA Hospital Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"McLaren","sequence":"additional","affiliation":[{"name":"Emory University in Atlanta Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William L.","family":"Grist","sequence":"additional","affiliation":[{"name":"Emory University in Atlanta Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luu","family":"Tran","sequence":"additional","affiliation":[{"name":"West Los Angeles VA Hospital Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Kuisk","sequence":"additional","affiliation":[{"name":"West Los Angeles VA Hospital Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890010203"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(79)90943-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060304"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.102.1.132"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947108000504"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197005000-00011"},{"key":"e_1_2_1_8_1","unstructured":"American Joint Committee for Cancer Staging and End\u2010Results Reporting (AJCCS). Chicago 1978 Manual for Staging Cancer pp27\u201344."}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988609400612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988609400612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:28:35Z","timestamp":1760970515000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988609400612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["10.1177\/019459988609400612"],"URL":"https:\/\/doi.org\/10.1177\/019459988609400612","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1986,6]]},"assertion":[{"value":"1986-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1986-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}