{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:39:08Z","timestamp":1788881948618,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":10944,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:p>Cat\u2010scratch disease has been reported with increasing frequency since its initial description in 1931. It is now recognized as being so prevalent that it probably represents the most common cause of unilateral lymphadenopathy in children, once nonspecific viral diseases and cutaneous infections have been excluded. The cardinal feature of the disease is a subacute regional granulomatous lymphadenitis. Because of its relatively mild natural course, most cases are treated on an outpatient basis. Forty\u2010four children, representing the more seriously ill portion of the disease spectrum, were treated at Texas Children's Hospital from 1972 to 1984 and constitute the data base for this article. Most patients were symptomatic for nearly 1\u00a0month prior to admission, typically complaining of low\u2010grade fever and regional lymphadenopathy. The two most common sites of lymph node involvement were the axilla (54%) and the neck (46%). Although there is, at this time, no specifically recommended treatment, 80% of patients received antibiotics and 70% underwent a surgical procedure\u2014usually total nodal excision. Nodal excision was followed by rapid resolution of symptoms. Because cat\u2010scratch disease is benign, surgery should be reserved for severe cases with signs of significant suppuration. Generally, symptomatic relief can be afforded by warm soaks and analgesics and recovery over the course of several weeks is uneventful.<\/jats:p>","DOI":"10.1177\/019459988609400616","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T09:31:49Z","timestamp":1499851909000},"page":"622-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cat\u2010Scratch Disease"],"prefix":"10.1002","volume":"94","author":[{"given":"James R.","family":"Spires","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Communicative Sciences Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.H.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Communicative Sciences Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)32153-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.207.2.312"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1970.02100050202002"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1954.02940490011003"},{"key":"e_1_2_1_6_1","first-page":"277","article-title":"Cat\u2010scratch disease","volume":"12","author":"Campbell JAH","year":"1977","journal-title":"Pathol Annu"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.42.5.803"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.1978.17.8.656"},{"key":"e_1_2_1_9_1","first-page":"968","article-title":"Cat\u2010scratch disease associated with an osteolytic lesion","volume":"137","author":"Carithers HA","year":"1983","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1978.02120370043011"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1971.00490010033004"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.111.6.736"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/224190a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.250.20.2745"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6612349"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.252.7.928"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195611292552203"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988609400616","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988609400616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:28:39Z","timestamp":1760970519000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988609400616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["10.1177\/019459988609400616"],"URL":"https:\/\/doi.org\/10.1177\/019459988609400616","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]},"assertion":[{"value":"1986-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}