{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:08:38Z","timestamp":1773248918442,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1987,1,1]],"date-time":"1987-01-01T00:00:00Z","timestamp":536457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:p>The primary histologic correlate of Meniere's disease is endolymphatic hydrops. From this, many investigators have postulated the existence of endolymphatic hypertension, although there have been no measurements published to substantiate this concept. Seventy guinea pigs, surgically treated with right endolymphatic duct obstruction, were later assessed by use of a micro\u2010electrode technique that measured their en\u2010dolabyrinthine hydrostatic pressures. For 21 of these animals, the pressures of both scala tympani (P<jats:sub>st<\/jats:sub>) and scala media (P<jats:sub>sm<\/jats:sub>) of both ears of each animal were successfully measured. Similar measurements were made in a control group of 25 guinea pigs that had not undergone any previous surgery. For normal ears\u2010as well as those with hy\u2010drops\u2010pressure differences between perilymph and endolymph (P<jats:sub>st<\/jats:sub> \u2010 P<jats:sub>sm<\/jats:sub>) varied around 0 &gt;2.0 mm Hg. When only the right (obstructed) ears were considered, there appeared to be a slight, relative pressure elevation (p &lt;0.05) in scala media during the first 7 days after endolymphatic duct obstruction\u2010and in those ears with EP, less than 70 mV. The magnitude of this pressure difference that can be attributed to the state of endolymphatic hydrops\u2010and not to natural variability\u2010is calculated (within 95% confidence limits) to be less than 0.5 mm Hg.<\/jats:p>","DOI":"10.1177\/019459988709600115","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T07:04:55Z","timestamp":1448435095000},"page":"83-95","source":"Crossref","is-referenced-by-count":57,"title":["Hydrostatic Pressure Measurements of Endolymph and Perilymph in a Guinea Pig Model of Endolymphatic Hydrops"],"prefix":"10.1002","volume":"96","author":[{"suffix":"III","given":"Charles H.","family":"Long","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Morizono","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Minnesota Minneapolis 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