{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:45:55Z","timestamp":1781196355445,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1987,11,1]],"date-time":"1987-11-01T00:00:00Z","timestamp":562723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:p>The surgical repair of subglottic stenosis (SGS) is often unsuccessful because of recurrence of the scar contracture. Over the past few years, two lathyrogenic agents (compounds that inhibit collagen cross\u2010linking) have been shown effective in prevention of stenosis in animal models that have deep caustic esophageal burns. Since the principles of induced lathyrism have not been applied to the treatment of laryngotracheal stenosis, a pilot study using a canine model was conducted to test the efficacy of penicillamine and <jats:italic>N<\/jats:italic>\u2010acetyl\u2010L\u2010cysteine in reduction of the rate of reformation of SGS. In all six animals used, a complete, 10 to 15 mm thick, mature SGS was induced experimentally, then opened with a Co<jats:sub>2<\/jats:sub> laser. The dogs that were treated with lathyrogenic agents exhibited a lower rate of re\u2010stenosis (one maintained patency throughout the 5 weeks of treatment) when compared to the two control dogs. Histologic sections of the subglottis in each dog revealed severe cricoid collapse, necrosis, and scarring, and thus demonstrated similarities to SGS in human beings. The two lathyrogenic agents used in this study are already approved for human use and may represent a valuable form of adjunctive therapy in the surgical management of SGS.<\/jats:p>","DOI":"10.1177\/019459988709700503","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T07:07:24Z","timestamp":1448435244000},"page":"446-451","source":"Crossref","is-referenced-by-count":12,"title":["Lathyrogenic Agents as Therapy for Subglottic Stenosis\u2014A Pilot Study"],"prefix":"10.1002","volume":"97","author":[{"given":"Gary L.","family":"Livingston","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Illinois at Chicago Eye and Ear Infirmary Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce A.","family":"Schild","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Illinois at Chicago Eye and Ear Infirmary Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1987,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"604","volume-title":"Diseases of the ear, nose, and throat","author":"Lederer FI","year":"1939"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947608500505"},{"key":"e_1_2_1_4_1","first-page":"491","volume-title":"Wound repair","author":"Peacock EE","year":"1984"},{"key":"e_1_2_1_5_1","first-page":"735","article-title":"Wound healing by primary intention in the larynx. 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