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To test the effect of fibrin glue on nerve regeneration without the confounding variables of distraction and\/or movement of the anastomosis, nerve repairs were performed with and without fibrin glue on the intratemporal facial nerve of the rat. The location of the nerve transection was the same for control and experimental nerves, but on the experimental side the nerve was repaired with fibrin glue and on the control side of the nerve was reapproximated in the fallopian canal, without glue or sutures. Axon counts distal to the repair revealed no statistically significant difference between the two methods of repair. This result suggests that mechnical obstruction by the fibrin glue between the nerve ends has a negligible effect on nerve regeneration.<\/jats:p>","DOI":"10.1177\/019459988910000205","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T06:02:21Z","timestamp":1439877741000},"page":"106-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Fibrin Glue on Rat Facial Nerve Regeneration"],"prefix":"10.1002","volume":"100","author":[{"given":"Glen","family":"Medders","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas E.","family":"Mattox","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Lyles","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1288\/00005537-198509000-00011","article-title":"Autologous fibrin tissue adhesive","volume":"95","author":"Siedentop KH","year":"1983","journal-title":"Laryngoscope"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1085293"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198609000-00015"},{"key":"e_1_2_1_5_1","first-page":"111","volume-title":"Biostatistical analysis","author":"Zar JH","year":"1984"},{"key":"e_1_2_1_6_1","first-page":"87","article-title":"Fibrin suture of peripheral nerves","volume":"2","author":"Young JZ","year":"1942","journal-title":"Lancet"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)62286-9"},{"key":"e_1_2_1_8_1","first-page":"366","article-title":"Plasma clot and silk suture of nerves","volume":"76","author":"Tarlov IM","year":"1943","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_9_1","first-page":"517","article-title":"Zur nahtlosen Interfaszikularen Nerventransplantation im Tierexperiment","volume":"122","author":"Matras J","year":"1972","journal-title":"Wien Med Wochenschr"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948609500109"},{"key":"e_1_2_1_11_1","first-page":"43","article-title":"Anatomy of the rat facial nerve","volume":"8","author":"Mattox DE","year":"1987","journal-title":"Am J Otol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988809800604"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988910000205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988910000205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:09:28Z","timestamp":1760965768000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988910000205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,2]]}},"alternative-id":["10.1177\/019459988910000205"],"URL":"https:\/\/doi.org\/10.1177\/019459988910000205","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,2]]},"assertion":[{"value":"1988-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}