{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:42:42Z","timestamp":1761007362577,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T00:00:00Z","timestamp":1477353600000},"content-version":"vor","delay-in-days":10008,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:p>Perichondritis of the pinna Is a serious late Infection of bums Involving the ear. The avascular nature of this Injury renders systemic antibiotic therapy Ineffective in delivering adequate levels of drug to the area to provide antimicrobial activity. Treatment has traditionally been surgery in some form, resulting in further disfigurement of the damaged cartllagenous framework. Iontophoresis, a method of dispersing charged particles through a relatively Impermeable membrane by a light electrical field, appears to be a feasible method of antibiotic delivery. This Initial pilot study Investigated the development of perlchondrltlc\u2010like burns in ten rabbit ears, and techniques for gentamlcln iontophoresis and assay in devitalized cartilage. Five rabbits, with ear bums simulating perichondritis, were treated with gentamlcln Iontophoresis on one ear and gentamlclnsoaked gauze on the other. Resulting assays of the ear cartilages, after four treatments over a 2\u2010day period, demonstrated a nearly twentyfold Increase in gentamlcln levels in the Iontophoresis\u2010treated ears, compared to low levels in the soaked ears. Systemic absorption was negligible in all rabbits.<\/jats:p>","DOI":"10.1177\/019459988910000608","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T06:47:51Z","timestamp":1500360471000},"page":"568-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antibiotic Iontophoresis in the Treatment of Burn Perichondritis of the Rabbit Ear"],"prefix":"10.1002","volume":"100","author":[{"given":"Russell A.","family":"Macaluso","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Geisinger Medical Center Danville Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas L.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Geisinger Medical Center Danville Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,25]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196808000-00003"},{"key":"e_1_2_1_3_1","first-page":"113","article-title":"Some clinical\u2010morphological specificities in pinna burns","volume":"23","author":"Troshev K","year":"1981","journal-title":"Acta Chir Plast"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90252-7"},{"key":"e_1_2_1_5_1","first-page":"664","article-title":"Perichondritis of the ear","volume":"85","author":"Martin R","year":"1975","journal-title":"Laryngoscope"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197402000-00009"},{"key":"e_1_2_1_7_1","first-page":"235","article-title":"Otologic aspect of ear bums","volume":"2","author":"Baers HA","year":"1981","journal-title":"Am J Otol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540740209"},{"key":"e_1_2_1_9_1","first-page":"1289","article-title":"Suppurative perichondritis of the auricle","volume":"76","author":"Wanamaker HH","year":"1972","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"volume-title":"Electronic ions and their use in medicine","year":"1908","author":"Leduc S.","key":"e_1_2_1_10_1"},{"key":"e_1_2_1_11_1","first-page":"500","article-title":"Experimental iontophoresis: Studies with radioisotopes","volume":"35","author":"O'Malley EP","year":"1954","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196511000-00006"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198066030-00005"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/58.1.32"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844318409052850"},{"key":"e_1_2_1_16_1","first-page":"277","article-title":"A morphological and histochemical study of the scalded hairy mouse ear","volume":"18","author":"Blomgren I","year":"1984","journal-title":"Scand J Plast Reconstr Surg"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844316809010490"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844317809012980"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.11.6.974"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/121.1.55"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988910000608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988910000608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:37:52Z","timestamp":1760963872000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988910000608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,6]]}},"alternative-id":["10.1177\/019459988910000608"],"URL":"https:\/\/doi.org\/10.1177\/019459988910000608","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1989,6]]},"assertion":[{"value":"1988-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}