{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:10:28Z","timestamp":1784693428512,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T00:00:00Z","timestamp":1477353600000},"content-version":"vor","delay-in-days":9886,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002595","name":"American Otological Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:p>Despite intensive investigation, the cause of otosclerosis remains uncertain. Recent studies of Paget's disease of bone have revealed a possible viral origin. Because of similarities between otosclerosis and Paget's disease, we have pursued investigation of a possible viral cause of otosclerosis. Four temporal bone specimens from patients with otosclerosis, processed for immunohistochemistry, demonstrated positive specific reactivity with monoclonal antibodies to measles virus antigens using the indirect immunofluorescent and immunoperoxidase techniques. Reactivity was most intense in active foci. Reactivity in the peroxidase assay was also observed in areas of active otosclerosis with application of primary antisera from patients with subacute sclerosing panencephalitis, a disorder of the central nervous system in which a defective measles virus has been isolated. Other related paramyxoviruses, including mumps and respiratory syncytial virus, were negative, as were negative controls.<\/jats:p>","DOI":"10.1177\/019459988910100401","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T06:45:34Z","timestamp":1500360334000},"page":"415-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Immunohistochemical Evidence of Measles Virus Antigens in Active Otosclerosis"],"prefix":"10.1002","volume":"101","author":[{"given":"Michael J.","family":"McKenna","sequence":"first","affiliation":[{"name":"Department of Otology and Laryngology Harvard Medical School Department of Otolaryngology, Massachusetts Eye and Ear Infirmary Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara G.","family":"Mills","sequence":"additional","affiliation":[{"name":"Bone Physiology Laboratory Orthopaedic Hospital and University of Southern California Schools of Dentistry and Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,25]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"262","volume-title":"The temporal bone and the ear","author":"Bast TH","year":"1949"},{"key":"e_1_2_1_3_1","first-page":"984","article-title":"Osteogenesis imperfecta congenita: Study of its histopathogenesis","volume":"9","author":"Weber M","year":"1930","journal-title":"Arch Pathol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948309200201"},{"key":"e_1_2_1_5_1","first-page":"25","article-title":"Filamentous structures morphologically similar to viral nucleocapsids in otosclerotic lesions in two patients","volume":"7","author":"McKenna MJ","year":"1986","journal-title":"Am J Otol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.959849"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198403000-00044"},{"key":"e_1_2_1_8_1","first-page":"225","article-title":"Mise en \u00e9vidence d'antig\u00e8nes viraux de rougeole dans les ost\u00e9oclastes de la maladie osseuse de Paget","volume":"289","author":"Basle M","year":"1979","journal-title":"C R Acad Sci (Paris)"},{"key":"e_1_2_1_9_1","first-page":"241","article-title":"Comparison between productive and latent subacute sclerosing panencephalitis viral infection in vitro: An electron microscopic and immunoperoxidase study","volume":"30","author":"Dubois\u2010Dalcq M","year":"1974","journal-title":"Lab Invest"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/221974a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-998631"},{"key":"e_1_2_1_12_1","first-page":"615","volume-title":"Persistent viruses","author":"Meulen V","year":"1978"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.223.13.1459"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988910100401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988910100401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:10:42Z","timestamp":1760969442000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988910100401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,10]]}},"alternative-id":["10.1177\/019459988910100401"],"URL":"https:\/\/doi.org\/10.1177\/019459988910100401","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,10]]},"assertion":[{"value":"1989-02-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}