{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T15:12:50Z","timestamp":1760973170615,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"6P1","license":[{"start":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T00:00:00Z","timestamp":1481587200000},"content-version":"vor","delay-in-days":8778,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:p>A significant number of patients undergo Irradiation to the temporal bone for malignancies. Conflicting reports exist regarding the effects of irradiation on hearing thresholds. Although radiation\u2010induced otitis media and osteoradionecrosis of the ossicles with resultant conductive hearing loss are well\u2010documented, there is disagreement regarding the effect of irradiation on sensorineural hearing. Previous animal models, relying only on behavioral tests and reflex thresholds, have failed to reveal consistent threshold shifts after irradiation. However, with the advent of auditory brainstem response (ABR) testing, a reliable objective measurement of hearing in animals is available. Hearing thresholds were determined bilaterally by ABR testing in 21 albino guinea pigs. The left temporal bones of sixteen animals were then Irradiated with a total dose ranging from 5750 to 7000 cGy over 7 weeks. The right ears of these animals, plus both ears of five nonlrradlated guinea pigs, served as controls. Follow\u2010up threshold ABRs were obtained immediately post\u2010irradlation (RT), and at 6 and 12 months post\u2010RT. Average thresholds in all groups increased over time: 60 dB in the control group; 53 dB in the control ears of the Irradiated animals; and 46 dB in the Irradiated ears. There were no statistically significant increases in ABR thresholds for Irradiated ears vs. control ears. At the 6\u2010month followup, hearing was actually better in the Irradiated ears than the control ears and this difference between ears was significantly greater than the difference at baseline (<jats:italic>p<\/jats:italic> &lt; 0.026). Overall, there was no evidence that irradiation produces changes in ABR thresholds.<\/jats:p>","DOI":"10.1177\/019459988910700610.1","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T16:20:22Z","timestamp":1483633222000},"page":"763-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of irradiation on guinea pig ABR thresholds"],"prefix":"10.1002","volume":"107","author":[{"given":"J. Scott","family":"Greene","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Geisinger Medical Center Danville Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil A.","family":"Giddings","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Geisinger Medical Center Danville Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Texas Health Science Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,13]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1423","article-title":"Glomus jugulare tumors: effect of irradiation","volume":"76","author":"Brackman DE","year":"1972","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700210"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540751206"},{"key":"e_1_2_1_5_1","first-page":"510","article-title":"Otolaryngologic sequelae of radiation therapy","volume":"57","author":"Kupperman GL","year":"1978","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/79.3.430"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100065233"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1960.03770050053008"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196608000-00010"},{"key":"e_1_2_1_10_1","first-page":"215","article-title":"Auditory effects of roentgen rays in dogs","volume":"30","author":"Girden E","year":"1933","journal-title":"Am J Roentgenol"},{"key":"e_1_2_1_11_1","first-page":"675","article-title":"Auditory effects of roentgen rays in dogs, II","volume":"32","author":"Girden E","year":"1935","journal-title":"Am J Roentgenol"},{"issue":"184","key":"e_1_2_1_12_1","article-title":"Radiation and the ear","author":"Kelemen G","year":"1963","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_1_13_1","first-page":"117","article-title":"Negligible effects of x\u2010radiation of the head upon hearing in the rat","volume":"1","author":"Murphy JE","year":"1961","journal-title":"J Aud Res"},{"key":"e_1_2_1_14_1","first-page":"15","article-title":"Sull'azione dei raggi x sulla chiocciola della cavia","volume":"62","author":"Novotny O","year":"1951","journal-title":"Arch Ital Otol Rinol Laringol"},{"key":"e_1_2_1_14_2","unstructured":"Acta Otolaryngol 1963 Suppl 184 Kelemen G. Radiation and the ear"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/3570371"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1962.03050370026006"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946107000121"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100064495"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197604000-00018"},{"key":"e_1_2_1_20_1","first-page":"1066","article-title":"Hearing loss after therapy with radiation","volume":"135","author":"Coplan I","year":"1981","journal-title":"Child"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100104086"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80681-0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1986.tb02030.x"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510010578X"},{"key":"e_1_2_1_25_1","first-page":"73","article-title":"Severe hearing loss due to cisplatin (DDP) administered after irradiation to inner ears","volume":"2","author":"McHaney V","year":"1983","journal-title":"ASCO Abstracts"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487509124650"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/139.4.418"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(84)90130-5"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988709600408"},{"key":"e_1_2_1_30_1","first-page":"326","article-title":"Generation of auditory brain stem responses (ABRs)","volume":"56","author":"Wada SI","year":"1983","journal-title":"I. Effects of injection of a local anesthetic (procaine HCl) into the trapezoid body of guinea pigs and cat. Electroencephalogr Clin Neurophysiol"},{"key":"e_1_2_1_31_1","first-page":"340","article-title":"Generation of auditory brain stem responses (ABRs)","volume":"56","author":"Wada SI","year":"1983","journal-title":"II. Effects of surgical section of the trapezoid body on the ABR in guinea pigs and cat. Electroencephalogr Clin Neurophysiol"},{"key":"e_1_2_1_32_1","first-page":"352","article-title":"Generation of auditory brain stem responses (ABRs)","volume":"56","author":"Wada SI","year":"1983","journal-title":"III. Effects of lesions of the superior olive, lateral lemniscus, and inferior colliculus on the ABR in guinea pig. Electroencephalogr Clin Neurophysiol"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488409130965"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00660737"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02565521"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988910700610.1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459988910700610.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:35:54Z","timestamp":1760970954000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459988910700610.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12]]},"references-count":35,"journal-issue":{"issue":"6P1","published-print":{"date-parts":[[1992,12]]}},"alternative-id":["10.1177\/019459988910700610.1"],"URL":"https:\/\/doi.org\/10.1177\/019459988910700610.1","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1992,12]]},"assertion":[{"value":"1992-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1992-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}