{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:16:30Z","timestamp":1790468190982,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T00:00:00Z","timestamp":1476489600000},"content-version":"vor","delay-in-days":9784,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["BNS\u20108419241"],"award-info":[{"award-number":["BNS\u20108419241"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS\u201024238"],"award-info":[{"award-number":["NS\u201024238"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>The perilymphatic spaces of guinea pig cochleae were perfused with artificial perilymph, with and without drug, at a rate of 2.5 \u03bcl\/minute for 10\u00a0minutes. The compound action potential of the auditory nerve, cochlear microphonics, and the summating potential evoked by 10\u00a0kHz tone bursts of varying intensities were recorded from a wire inserted in the basal turn scala vestibull. The endocochlear potential was recorded from the scala media. Sodium salicylate (1.25 to 10\u00a0mmol\/L) reduced the magnitude of the compound action potential evoked by low\u2010sound intensities without affecting the compound action potential evoked by high\u2010sound intensities. Sodium salicylate also reduced cochlear microphonics and had no effect on summating potential. Cochlear perfusions of prostaglandin synthesis inhibitors, mefenamate (200 \u03bcmol\/L), and meclofenamate (200 \u03bcmol\/L), had no effect on the cochlear potentials. Quinine (10 to 100 \u03bcmol\/L) reduced the compound action potential input\u2010output function in a parallel fashion rather than selectively affecting the low\u2010intensity compound action potential. Quinine (100 \u03bcmol\/L) reduced cochlear microphonics and summating potential. Neither quinine (100 \u03bcmol\/L) nor salicylate (5\u00a0mmol\/L) affected endocochlear potential. These results suggest that salicylate\u2010induced hearing loss is not caused by either antagonism of the hair cell transmitter or cyclooxygenase inhibition, nor is it caused by the same mechanism that causes quinine\u2010induced hearing loss.<\/jats:p>","DOI":"10.1177\/019459989010200110","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T13:34:17Z","timestamp":1500298457000},"page":"66-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Salicylate, mefenamate, meclofenamate, and quinine on cochlear potentials"],"prefix":"10.1002","volume":"102","author":[{"given":"Jean\u2010Luc","family":"Fuel","sequence":"first","affiliation":[{"name":"Louisiana State University Medical School, Kresge Hearing Research Laboratory of the South Department of Otorhinolaryngology and Biocommunication New Orleans Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Bobbin","sequence":"additional","affiliation":[{"name":"Louisiana State University Medical School, Kresge Hearing Research Laboratory of the South Department of Otorhinolaryngology and Biocommunication New Orleans Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Fallon","sequence":"additional","affiliation":[{"name":"Louisiana State University Medical School, Kresge Hearing Research Laboratory of the South Department of Otorhinolaryngology and Biocommunication New Orleans Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,15]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.394391"},{"key":"e_1_2_1_3_1","first-page":"73","article-title":"Comparative actions of salicylate on the amphibian lateral line and guinea pig cochlea.","volume":"93","author":"Puel J\u2010L","year":"1989","journal-title":"Comp Biochem 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ototoxic drugs on the concentrations of prostaglandins in the perilymph [Abstract]."},{"key":"e_1_2_1_17_1","first-page":"190","article-title":"Ototoxicity: a contemporary review of aminoglycosides, loop diuretics, acetylsalicylic acid, quinine, erythromycin, and cisplatinum.","volume":"6","author":"Koegel L","year":"1985","journal-title":"Am J Otol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.124.1.33"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015218"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(86)90095-X"},{"key":"e_1_2_1_21_1","first-page":"231","volume-title":"Pharmacology of hearing.","author":"Bobbin RP","year":"1981"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00206097309071651"}],"container-title":["Otolaryngology\u2013Head and Neck 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