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Photodynamic therapy consists of the intravenous administration of (di)hematoporphyrin ether, a chemosensitizing drug selectively retained by neoplastic and reticuloendothelial tissues which, when exposed to a 630\u2010nm argon laser, catalyzes a photochemical reaction to release free oxygen radicals, \u201cthe cytotoxic\u201d agents responsible for cell death and tumor necrosis. Preliminary investigations have assessed the efficacy of photodynamic therapy in treatment of: (1) superficial \u201ccondemned mucosa\u201d or \u201cfield cancerization\u201d of the oral cavity and (2) stage III and IV head and neck carcinomas that had unsuccessful conventional therapy. Complete and\/or partial remissions were obtained in 11 of 12 patients (16 treatments) with a variety of carcinomas of the nasopharynx, palate and uvula, retromolar trigone, temporal bone, cervical esophagus, and AIDS\u2010related Kaposi's sarcoma of the oral cavity.<\/jats:p>","DOI":"10.1177\/019459989010200304","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T12:35:03Z","timestamp":1500294903000},"page":"225-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Photodynamic therapy for treatment of head and neck cancer"],"prefix":"10.1002","volume":"102","author":[{"given":"Vanessa Gayl","family":"Schweitzer","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Henry Ford Hospital Detroit 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