{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:17:34Z","timestamp":1786925854264,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1990,4,1]],"date-time":"1990-04-01T00:00:00Z","timestamp":638928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:p>Severe stomatitis is a common problem encountered during either radiation therapy or chemotherapy. Most therapeutic regimens are empirical, with no scientific basis. The purpose of this study is to determine the efficacy of various topical solutions in the treatment of radiation\u2010 or chemotherapy\u2010induced stomatitis. Eighteen patients were entered into a prospective double\u2010blinded study to test several topical solutions: (1) viscous lidocaine with 1% cocaine; (2) dyclonine hydrochloride 1.0% (Dyclone); (3) kaolin\u2010pectin solution, diphenhydramine plus saline (KBS); and (4) a placebo solution. Degree of pain relief, duration of relief, side effects, and palatability were evaluated. The results showed that Dyclone provided the most pain relief. Dyclone and viscous lidocaine with 1% cocaine provided the longest pain relief, which averaged 50\u00a0minutes This study provides objective data and defines useful guidelines for treatment of stomatitis.<\/jats:p>","DOI":"10.1177\/019459989010200404","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T06:42:21Z","timestamp":1448433741000},"page":"326-330","source":"Crossref","is-referenced-by-count":43,"title":["Treatment of Radiation\u2010 and Chemotherapy\u2010Induced Stomatitis"],"prefix":"10.1002","volume":"102","author":[{"given":"Shirley B.","family":"Carnel","sequence":"first","affiliation":[{"name":"Department of Otolaryngoloyg\u2014Head and Neck Surgery Service Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don B.","family":"Blakeslee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngoloyg\u2014Head and Neck Surgery Service Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Oswald","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Service Fitzsimons Army Medical Center Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy Department Fox Chase Cancer Center Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1990,4]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1309","article-title":"Intra\u2010oral problems associated with head and neck irradiation for malignant disease in children and adolescents","volume":"225","author":"Braham RL","year":"1981","journal-title":"Practitioner"},{"key":"e_1_2_1_3_1","first-page":"143","article-title":"Complications of chemotherapeutic agents","volume":"30","author":"Adrian RM","year":"1980","journal-title":"CA"},{"key":"e_1_2_1_4_1","first-page":"14","article-title":"Dealing with oral complications in irradiated cancer patients","author":"Schaaf JE","year":"1982","journal-title":"Alumi Bulletin IUND"},{"key":"e_1_2_1_5_1","first-page":"93","article-title":"Relief of antineoplastic therapy\u2010induced stomatitis pain with low concentration topical cocaine","volume":"2","author":"Artim R","year":"1983","journal-title":"Proceedings ASCO"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-2-199"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197602)37:2 <1186::AID-CNCR2820370830>3.0.CO;2-V"},{"key":"e_1_2_1_8_1","first-page":"313","article-title":"Roentgen therapy of epitheliomas of tonsillar regions, hypopharynx, and larynx, from 1920 to 1926","volume":"28","author":"Coutard H","year":"1932","journal-title":"Am J Roentgenol"},{"key":"e_1_2_1_9_1","first-page":"121","volume-title":"Clinical radiation pathology","author":"Rubin P","year":"1968"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989010200404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989010200404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:14:21Z","timestamp":1760966061000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989010200404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,4]]}},"alternative-id":["10.1177\/019459989010200404"],"URL":"https:\/\/doi.org\/10.1177\/019459989010200404","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,4]]}}}