{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:47:03Z","timestamp":1767649623337,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":9427,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:p>The recognition of a second primary carcinoma in a patient with known head and neck cancer is considered a poor prognostic sign. However, its true implication for patient survival is not known. A retrospective 10\u2010year study showed that second primary malignancies developed in 207 of 875 patients. Second primary malignancies were most commonly associated with glottic index tumors, followed by floor of mouth tumors. The second primary was most likely to occur at a time interval of 1.5 years from diagnosis of the index tumor. Second primary neoplasms were more likely to develop in patients whose original head and neck tumor was stage I or II, or whose histopathology showed well or moderately well differentiation. Patients with head and neck cancer in whom a second upper aerodigestive tract tumor develops have a 75% chance of 1\u2010year survival, but only a 25% chance of 5\u2010year survival. The average time from diagnosis of second primary to the time of death was 2.3 years. If we are to increase the survival time of our patients with head and neck cancer, we must consider that a second primary will develop in one of four patients. We must therefore consider the high risk of second primary malignancy when formulating the original treatment plan for a patient manifesting his or her first head and neck cancer.<\/jats:p>","DOI":"10.1177\/019459989010300103","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T21:36:04Z","timestamp":1460151364000},"page":"14-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Survival Statistics for Multiple Primaries in Head and Neck Cancer"],"prefix":"10.1002","volume":"103","author":[{"given":"Jeannie T.","family":"Larson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George L.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham Abdel","family":"Fattah","sequence":"additional","affiliation":[{"name":"University of Alexandria Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"980","volume-title":"Die allgemeine chirurgische Pathologie und Therapie, in 51 Vorlesungen: Ein Handbuch f\u00fcr Studierende und Aerzte","author":"Billroth T","year":"1882"},{"key":"e_1_2_1_3_1","first-page":"1358","article-title":"Multiple primary malignant tumors: A survey of the literature and statistical study","volume":"51","author":"Warren S","year":"1932","journal-title":"Am J Cancer"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM193312072092303"},{"key":"e_1_2_1_5_1","first-page":"133","article-title":"Multicentric origin of intra\u2010oral carcinoma","volume":"20","author":"Slaughter DP","year":"1946","journal-title":"Surgery"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348944705600405"},{"issue":"26","key":"e_1_2_1_7_1","first-page":"844","article-title":"Doppelkarzinome in Larynx und Lungen","volume":"105","author":"Pelloni S","year":"1975","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196103\/04)14:2<221::AID-CNCR2820140202>3.0.CO;2-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1979.00790220031007"},{"key":"e_1_2_1_10_1","first-page":"263","article-title":"Incidence of multiple primary cancers. 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