{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:02:07Z","timestamp":1792083727244,"version":"4.4.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":9335,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010NS52387"],"award-info":[{"award-number":["N01\u2010NS52387"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32\u2010NS07293"],"award-info":[{"award-number":["T32\u2010NS07293"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01\u2010NS21440"],"award-info":[{"award-number":["P01\u2010NS21440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:p>The availability of thin\u2010film multichannel electrodes provides new possibilities for implantation and direct stimulation of the modiolar portion of the auditory nerve. Electrodes in direct contact with the auditory nerve should be functional at lower thresholds and might require fewer remaining neurons for stimulation compared to electrodes in the scala tympani. This strategy would also provide close contact with neural elements subserving a greater frequency range. Implantation of the eighth nerve may also be advantageous in profoundly deaf subjects who lack an implantable scala tympani. In this study we evaluated the effect of surgical implantation and chronic placement of a silicon substrate implant in the modiolar portion of the auditory nerve of the guinea pig. Of six chronically implanted ears, five showed changes limited to the loss of spiral ganglion cells in the canal of Rosenthal, immediately adjacent to the Implant. The sixth ear showed more extensive cochlear alteration in a pattern suggestive of vascular injury. In separate acute experiments, implants were placed in the modiolar portion of the auditory nerve and electrophysiologic analysis was performed. Middle latency responses with good morphology were obtained at thresholds below those found with scala tympani implants. Input\u2010output functions exhibited a plateau in response amplitude at stimulus levels below thresholds for seventh or vestibular portion of the eighth nerve. Further modifications of the modiolar portion of the auditory nerve electrode design will include development of an electrode interconnect that will allow chronic implantation with stimulation.<\/jats:p>","DOI":"10.1177\/019459989010300408","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T12:40:47Z","timestamp":1461242447000},"page":"575-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of a silicon\u2010substrate modiolar eighth nerve implant in a guinea pig"],"prefix":"10.1002","volume":"103","author":[{"given":"John J.","family":"Zappia","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Kresge Hearing Research Institute University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamille F.","family":"Hetke","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kresge Hearing Research Institute University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Altschuler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kresge Hearing Research Institute University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Niparko","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kresge Hearing Research Institute University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"14","article-title":"Prostheses auditive par excitation electrique a distance due nerf sensorial a l'aude d'un babinage inclus a demeure","volume":"35","author":"Djourno A","year":"1957","journal-title":"Presse Med"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1964.00750030572003"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1980.00790280001001"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800290024005"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.32101"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988910100607"},{"key":"e_1_2_1_8_1","first-page":"543","article-title":"Surgical implantation and biocompatibility of CNS auditory prosthesis","volume":"13","author":"Niparko JK","year":"1987","journal-title":"Soc Neurosci (Abstr)"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948909801209"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(83)80013-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948609500204"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988910100110"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989010300408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989010300408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:28:14Z","timestamp":1760970494000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989010300408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,10]]}},"alternative-id":["10.1177\/019459989010300408"],"URL":"https:\/\/doi.org\/10.1177\/019459989010300408","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,10]]},"assertion":[{"value":"1989-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1990-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}