{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:24:26Z","timestamp":1791177866714,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":9274,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:p>The permeability of the round window membrane (RWM) was studied by using horseradish peroxidase (HRP) in the different stages of otitis media developed in guinea pigs, and it was compared with normal RWM under transmission electron microscopic examination. The experimental model of otitis media was developed by inoculation of a <jats:italic>Pseudomonas aeruginosa<\/jats:italic> suspension. When HRP could penetrate into the inner layer of a normal RWM, the duration of HRP instillation into the round window niche was 10\u00a0minutes. The permeability of the RWM in otitis media was as follows: 3\u2010day animals showed penetration of HRP into the middle layer. In 1\u2010week animals, HRP had penetrated into the inner layer in all 10 ears. In 2\u2010week animals, HRP had penetrated into the inner layer in 6 of 11 ears. In 4\u2010week animals, however, HRP was not seen in 6 of 7 ears. HRP had penetrated through the damaged focus of the epithelial cells by inflammation. These results suggest that any derangement of the epithelial linings could increase the penetration of HRP and also ototoxic materials into the inner ear through the RWM.<\/jats:p>","DOI":"10.1177\/019459989010300606","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T21:30:00Z","timestamp":1460151000000},"page":"918-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Permeability of the round window membrane to horseradish peroxidase in experimental otitis media"],"prefix":"10.1002","volume":"103","author":[{"given":"Chong Sun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otolaryngology College of Medicine Seoul National University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai Kwon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology College of Medicine Seoul National 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