{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:44:49Z","timestamp":1761007489094,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":9274,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:p>The distribution of neuropeptide immunoreactive nerve fibers in the canine larynx was examined. In the epithelium of supra\u2010 and subglottic regions, a dense distribution of substance P (SP)\u2010 and calcitonin gene\u2010related polypeptide (CGRP)\u2010immunoreactive (IR) nerve fibers was observed. Some vasoactive intestinal polypeptide (VIP)\u2010IR intraepithelial nerve fibers were also seen in the subglottic region. In the laryngeal glands, a dense distribution of VIP\u2010IR nerve fibers with a few SP\u2010 and enkephalin (ENK)\u2010IR nerve fibers were found around the acini. In the walls of arteries in the lamina propria, many VIP\u2010, SP\u2010, and CGRP\u2010IR nerve fibers were seen, whereas neuropeptide Y\u2010, ENK\u2010, and VIP\u2010IR nerve fibers were predominantly distributed around the arteries in the vocal muscle. In the free edge of the vocal cord, few immunoreactive nerve fibers were detected within the epithelium and around the arteries in the lamina propria. These results suggest that there are regional differences in the occurrence of peptides in nerve fibers innervating the epithelium and the blood vessels in the larynx and that the perception mechanism of the epithelium and the regulatory system of local blood flow are varied according to their location in the larynx.<\/jats:p>","DOI":"10.1177\/019459989010300612","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T21:30:00Z","timestamp":1460151000000},"page":"957-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Distribution of neuropeptide\u2010like immunoreactive nerve fibers in the canine larynx"],"prefix":"10.1002","volume":"103","author":[{"given":"Michiru","family":"Kawasoe","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology Saga Medical School Nabeshima Japan"},{"name":"Departments of Otolaryngology Saga Medical School Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takemoto","family":"Shin","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology Saga Medical School Nabeshima Japan"},{"name":"Departments of Otolaryngology Saga Medical School Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadahiko","family":"Masuko","sequence":"additional","affiliation":[{"name":"Departments of Anatomy Saga Medical School Nabeshima Japan"},{"name":"Departments of Anatomy Saga Medical School Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600405"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1968.tb56752.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487809124767"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(84)90090-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488209130861"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988709700107"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988910100608"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90285-X"},{"key":"e_1_2_1_10_1","first-page":"391","volume-title":"Handbook of chemical neuroanatomy. 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