{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:23Z","timestamp":1787018723830,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1991,3,1]],"date-time":"1991-03-01T00:00:00Z","timestamp":667785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS\u201022042"],"award-info":[{"award-number":["NS\u201022042"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:p>Labyrinthitis ossificans may be a hindrance to cochlear implantation by making electrode insertion difficult. We performed a histopathologic study of 24 temporal bones with labyrinthitis ossificans from multiple causes. The organ of Corti was graphically reconstructed and the degree of obstruction was estimated for each millimeter of the cochlea. Correlations were calculated between the degree of new bone formation and the cause, patient's age and sex, and time from the original temporal bone insult. Our results demonstrate that complete cochlear ossification is rare. The scala tympani in the basal turn of the cochlea is the most frequent area of ossification, regardless of the cause of the labyrinthitis ossificans. Meningogenic labyrinthitis, usually a childhood disease, was associated with the greatest amount of ossification. When ossification resulted from tympanogenic labyrinthitis, the scala tympani was completely ossified near the round window niche in all temporal bones. Neo\u2010ossification of the basal turn associated with otosclerosis was limited to the proximal 6\u00a0mm of the scala tympani in all cases. Three temporal bones had a patent round window niche and basal turn, but significant apical and middle\u2010turn ossification. Peripheral sensorineural elements were severely degenerated in the region of the ossification in all specimens, and spiral ganglion cell counts were decreased.<\/jats:p>","DOI":"10.1177\/019459989110400306","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T06:43:17Z","timestamp":1448433797000},"page":"320-326","source":"Crossref","is-referenced-by-count":99,"title":["Labyrinthitis ossificans: Histopathologic consideration for cochlear implantation"],"prefix":"10.1002","volume":"104","author":[{"suffix":"Jr.","given":"J. Douglas","family":"Green","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic and and Mayo Foundation, Rochester Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S.","family":"Marion","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic and and Mayo Foundation, Rochester Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fcl","family":"Hinojosa","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Otolaryngology\u2010Head and Neck Surgery University of Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1991,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947708600105"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600303"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(86)80012-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348945806700101"},{"key":"e_1_2_1_6_1","first-page":"95","article-title":"Bildungsanomalien im h\u00e4utigen Labyrinth bei Taub\u2010stummheit","volume":"27","author":"Scheibe A","year":"1895","journal-title":"Zeitschr Ohrenh"},{"key":"e_1_2_1_7_1","first-page":"192","article-title":"Ein Fall von Zerst\u00f6rung und theilweiser Verkn\u00f6cherung beider Labyrinthe, muthmasslich in Folge einer Meningitis","volume":"22","author":"Steinbr\u00fcgge H","year":"1892","journal-title":"Zeitschr Ohrenh"},{"key":"e_1_2_1_8_1","first-page":"102","volume-title":"Handbuch der speziellen pathologischen Anatomie und Histologie. 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