{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:47:30Z","timestamp":1761648450490,"version":"build-2065373602"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":9088,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:p>The involved membranous labyrinth of patients with medically intractable Meniere's disease is being accessed by means of a fenestration of the bony horizontal semicircular canal in preparation for the application of a 125 or 250\u00a0mcg flake of solid streptomycin. Sensory information originating in the affected vestibular end organ is selectively blocked from reaching the central nervous system. This uniformly results in the rapid elimination of vertiginous symptoms, and at these calculated doses yields preservation of (or in some cases improvement in) preoperative cochlear thresholds. The rationale for this procedure, as detailed in earlier investigations of animals, will be briefly reviewed before highlighting our preliminary results in adult clinical trials.<\/jats:p>","DOI":"10.1177\/019459989110500115","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T03:44:16Z","timestamp":1499053456000},"page":"107-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Selective chemical vestibulectomy: Preliminary results with human application"],"prefix":"10.1002","volume":"105","author":[{"given":"Ronald G.","family":"Amedee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Tulane University School of Medicine New Orleans Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H.","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Tulane University School of Medicine New Orleans Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Risey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Tulane University School of Medicine New Orleans Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1927.00610010329001"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1964.00750030347004"},{"key":"e_1_2_1_4_1","first-page":"39","article-title":"Surgical treatment of Meniere's disease since Thomsen","volume":"9","author":"Smith WC","year":"1988","journal-title":"Am J Otol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197409000-00011"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988910100102"},{"key":"e_1_2_1_7_1","first-page":"23","article-title":"Retrolabyrinthine vestibular neurectomy with and without monitoring of eighth nerve potentials","volume":"6","author":"McDaniel AB","year":"1985","journal-title":"Am J Otol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195607000-00005"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988409200413"},{"key":"e_1_2_1_10_1","first-page":"84","article-title":"Application of streptomycin to the lateral semicircular canal","volume":"75","author":"Norris CH","year":"1988","journal-title":"Trans Am Otol Soc"},{"key":"e_1_2_1_11_1","first-page":"395","article-title":"Selective chemical vestibulectomy","volume":"11","author":"Amedee RG","year":"1990","journal-title":"Am J Otol"},{"key":"e_1_2_1_12_1","first-page":"89","article-title":"Perfusion of the inner ear with streptomycin","volume":"75","author":"Shea JJ","year":"1988","journal-title":"Trans Am Otol Soc"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988509300501"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989110500115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989110500115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:29:41Z","timestamp":1760963381000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989110500115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1177\/019459989110500115"],"URL":"https:\/\/doi.org\/10.1177\/019459989110500115","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1991,7]]},"assertion":[{"value":"1990-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1991-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}