{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:29:38Z","timestamp":1773826178961,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":9026,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1991,9]]},"abstract":"<jats:p>A study of 1452 human temporal bones revealed a previously unpublished material of 144 bones with otosclerosis. After exclusion of infants and individuals of races other than white, the incidence of otosclerosis was 12.75%. Of the bones with otosclerosis, 56.1% belonged to men and 43.9% to women. The incidence of clinical and histologic otosclerosis was practically the same for men (44.7% to 55.3%) as for women (47% to 53%). However, the incidence of bilateral otosclerosis was higher in women (88.9%) than in men (65.2%). Bilateral otosclerosis was present in 75.6%, whereas it was unilateral in 24.4%. Sixty\u2010six (66) ears (45.8%) had clinical otosclerosis, whereas 78 (54.2%) had histologic otosclerosis\u2014frequently unifocal lesions. The most common site was anterior to the oval window (117 ears, 81.25%), followed by round window niche (52 ears, 36.11%), apical and medial cochlear wall (31 ears, 21.52%), and anterior wall of the internal auditory canal (27 ears, 18.75%). The activity of lesions was directly related to their size. Smaller lesions were predominantly inactive, whereas medium and larger lesions were predominantly active. There was a positive correlation when the size of the lesions, activity, and degree of cochlear endosteal involvement were compared with bone conduction thresholds (37 cases). Correlations between size and activity, and between activity and associated sensorineural hearing loss did not necessarily follow the sequence of an initial active stage (spongiotic) to a final inactive one (sclerotic). Comparison of cases of otosclerosis with equivalent age groups of the normal population yielded worse bone conduction thresholds for the otosclerosis cases only in the age group 60 to 69 years and older. Comparison of average bone conduction thresholds between bones with one site of endosteal involvement (28.26 dB HL) revealed no significant differences. Bones with two or more sites of endosteal involvement had significant differences. Bones with two or more sites of endosteal involvement had significantly worse bone conduction thresholds (62 dB HL). The overall results are not suggestive of an association of sensorineural hearing loss with otosclerosis without stapedial fixation.<\/jats:p>","DOI":"10.1177\/019459989110500308","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T23:42:56Z","timestamp":1485474176000},"page":"396-405","source":"Crossref","is-referenced-by-count":73,"title":["Otosclerosis: The University of Minnesota Temporal Bone Collection"],"prefix":"10.1002","volume":"105","author":[{"given":"Marcelo M.","family":"Hueb","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Minnesota Edina Minnesota"},{"name":"Department of Otolaryngology University of Sao Paulo Riberao Prest Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos V.","family":"Goycoolea","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Minnesota Edina Minnesota"},{"name":"Minnesota Ear Head and Neck Clinic University of Sao Paulo Riberao Prest Brazil"},{"name":"Audia Chile and Clinica Las Condes Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Paparella","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Minnesota Edina Minnesota"},{"name":"Minnesota Ear Head and Neck Clinic University of Sao Paulo Riberao Prest Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Sao Paulo Riberao Prest Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"267","article-title":"Totaler Knocherner Verschluss beider. Labyrinth\u2010fenster und Labyrinthitis Serosa infolge Prgessiver Spongiosierumg","author":"Siebenmann F","year":"1911","journal-title":"Verhandl Dtsch Ges Otol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540751012"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770020366023"},{"key":"e_1_2_1_5_1","first-page":"1","article-title":"Otosclerosis: An electron microscopic and cytochemical study","volume":"272","author":"Chevance L","year":"1970","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)32578-0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947508400415"},{"key":"e_1_2_1_8_1","first-page":"356","article-title":"Does otosclerosis cause cochlear nerve degeneration?","volume":"57","author":"Guild SR","year":"1953","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197405000-00008"},{"key":"e_1_2_1_10_1","first-page":"81","article-title":"Cochlear otosclerosis: An intractable absurdity","volume":"8","author":"Schuknecht HF","year":"1983","journal-title":"J Laryngol Otol"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198511000-00003"},{"key":"e_1_2_1_12_1","first-page":"1","volume-title":"Hearing and balance in the elderly","author":"Davis A","year":"1983"},{"key":"e_1_2_1_13_1","first-page":"246","article-title":"Histologic otosclerosis","volume":"53","author":"Guild S","year":"1944","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"e_1_2_1_14_1","first-page":"351","volume-title":"Pathology of the ear","author":"Schuknecht HF","year":"1974"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100046533"},{"key":"e_1_2_1_16_1","first-page":"1","article-title":"The histology of otosclerotic ankylosis of the stapes with regards to its surgical mobilization","volume":"4","author":"Ruedi L","year":"1957","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770020343022"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195401000-00005"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946607500213"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988108900239"},{"key":"e_1_2_1_21_1","first-page":"51","article-title":"Pathology and pathogenesis of sensorineural deafness in otosclerosis","volume":"29","author":"Linthicum FH","year":"1967","journal-title":"EENT Digest"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948409300201"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948409300104"},{"key":"e_1_2_1_24_1","first-page":"1489","volume-title":"Otolaryngology","author":"Goycoolea MV","year":"1991"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198306000-00003"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000414108"},{"key":"e_1_2_1_27_1","first-page":"464","article-title":"Densitometry of the cochlear capsule and correlation between bone density loss and bone conduction hearing loss in otosclerosis","volume":"103","author":"Huizing EH","year":"1987","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197811000-00006"},{"key":"e_1_2_1_29_1","first-page":"84","article-title":"Cochlear otosclerosis","volume":"8","author":"Causse JB","year":"1983","journal-title":"J Laryngol Otol"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989110500308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989110500308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:00:55Z","timestamp":1760958055000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989110500308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,9]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,9]]}},"alternative-id":["10.1177\/019459989110500308"],"URL":"https:\/\/doi.org\/10.1177\/019459989110500308","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,9]]}}}