{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:31:50Z","timestamp":1763037110353,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":8965,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:p>Malignant hyperthermia (MH) is an adverse reaction most frequently associated with the administration of halogenated inhalational anesthetic agents and the depolarizing muscle relaxant succinylcholine. Characteristic findings are a hypermetabolic state accompanied by extreme hyperpyrexia, acidosis, rhabdomyolysis, and generalized muscle rigidity, often involving the masseter muscles. Dantrolene sodium, which was approved in 1979 by the FDA for use in the prevention of MH in high\u2010risk patients, has neurologic and gastrointestinal side effects. At the Children's National Medical Center (CNMC), 24 children identified as being at risk for the development of a MH reaction were anesthetized for otolaryngic procedures by using \u201cnon\u2010triggering\u201d anesthetics and without use of dantrolene sodium. These patients represent 56% of all patients at risk for MH or masseter muscle rigidity (MMR) reactions during an 8\u2010year period at the CNMC. There were no complications. Concomitant muscle biopsies were performed, and caffeine\/halothane contracture studies were completed in 18 of these patients, demonstrting 11 susceptible or equivocal responses. The data suggest that children undergoing common otolaryngic procedures who are at risk for development of MH may be safely anesthetized without the use of prophylactic dantrolene sodium.<\/jats:p>","DOI":"10.1177\/019459989110500508","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T22:17:16Z","timestamp":1499897836000},"page":"680-686","source":"Crossref","is-referenced-by-count":9,"title":["Management of Otolaryngic Patients Susceptible to Malignant Hyperthermia Without Dantrolene"],"prefix":"10.1002","volume":"105","author":[{"given":"Craig S.","family":"Derkay","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Eastern Virginia Medical Center Norfolk Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M.","family":"Grundfast","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Department of Surgery George Washington University School of Medicine Bethesda Maryland"},{"name":"Department of Pediatric Otolaryngology Children's National Medical Center Washington D. 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