{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:32:23Z","timestamp":1791462743225,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":8875,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:p>The clinical nature of laryngeal amyloidosis has not been well established, and the natural history of the disease remains a controversial matter. To address these issues, we reviewed the clinicopathologic and immunohistochemical features of 22 cases (11 men and 11 women; mean age, 56 years) of laryngeal amyloidosis. Hoarseness was the most common symptom, and the most frequent site affected was the false vocal cords. Six patients had concomitant tracheal amyloidosis. Paraffin blocks were available for immunostaining in 20 cases. Nineteen cases were positive for amyloid P component. \u03bb\u2010Light chains were detected in 12 cases and \u03ba\u2010light chains in 5; three cases did not show definite light\u2010chain staining. Ten patients underwent repeated operations for persistent or recurrent respiratory tract disease. One patient died of progressive tracheobronchial amyloidosis, but systemic amyloidosis did not develop in any of the patients. Laryngeal amyloidosis is a form of localized amyloidosis characterized by monoclonal light\u2010chain deposition. Recurrent respiratory tract disease is not uncommon, but the usual clinical course is relatively benign.<\/jats:p>","DOI":"10.1177\/019459989210600410","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T03:58:05Z","timestamp":1485575885000},"page":"372-377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Laryngeal Amyloidosis: A Clinicopathologic and Immunohistochemical Review"],"prefix":"10.1002","volume":"106","author":[{"given":"Jean E.","family":"Lewis","sequence":"first","affiliation":[{"name":"Section of Surgical Pathology Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry D.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul 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