{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:35:16Z","timestamp":1761006916444,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:p>Patients with Meniere's disease were investigated for possible immunologic abnormalities. A total of 104 cases\u201455 bilateral and 49 unilateral\u2014were examined. Immune activity was assessed using four types of immune parameters: (1) the erythrocyte sedimentation rate (ESR) and C\u2010reative protein levels (CRP); (2) serum immunoglobulin levels (IgG, IgM, and IgA); (3) complement levels (C3, C4, and CH50); and (4) autoantibody levels (rheumatoid factor, anti\u2010DNA antibody, and antinuclear antibody). Patients with severe immunologic abnormalities (16% of the bilateral cases and 2% of the unilateral cases) typically displayed bilateral severe hearing loss, bilateral decreased vestibular response, and excellent responsiveness to steroid treatment. As patients with bilateral involvement account for approximately 30% of all cases of Meniere's disease in Japan, immunologic involvement may be assumed in about 6% of the total. The severity of these patients' symptoms and their responsiveness to steroid treatment suggest that the possibility of immunologic involvement is well worth investigation in Meniere's disease.<\/jats:p>","DOI":"10.1177\/019459989210700109","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T06:45:34Z","timestamp":1448433934000},"page":"57-62","source":"Crossref","is-referenced-by-count":16,"title":["Immunologic Abnormality in Meniere's Disease"],"prefix":"10.1002","volume":"107","author":[{"given":"Mikio","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Shiga University of Medical Science Seta Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Shiga University of Medical Science Seta Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,7]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_1","DOI":"10.1177\/000348947908800501"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_1","DOI":"10.1126\/science.7112122"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_1","DOI":"10.1126\/science.6623056"},{"key":"e_1_2_1_5_1","first-page":"254","article-title":"Autoimmune sensorineural hearing loss as an aggravating factor in Meniere's disease","volume":"30","author":"Shea JJ","year":"1983","journal-title":"Adv Otorhinolaryngol"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_1","DOI":"10.1177\/019459988809800308"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_1","DOI":"10.1288\/00005537-198605000-00006"},{"key":"e_1_2_1_8_1","first-page":"82","article-title":"Autoimmune inner ear disease: fact or fantasy?","volume":"46","author":"Hughes GB","year":"1991","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_1_9_1","first-page":"163","volume-title":"Meniere's disease: pathogenesis, diagnosis, and treatment","author":"Kitahara M","year":"1981"},{"doi-asserted-by":"publisher","key":"e_1_2_1_10_1","DOI":"10.1080\/00016489.1985.12005661"},{"doi-asserted-by":"publisher","key":"e_1_2_1_11_1","DOI":"10.1007\/978-4-431-68111-3_2"},{"doi-asserted-by":"publisher","key":"e_1_2_1_12_1","DOI":"10.1001\/archotol.1986.03780050060010"},{"doi-asserted-by":"publisher","key":"e_1_2_1_13_1","DOI":"10.1177\/000348949009900707"},{"doi-asserted-by":"publisher","key":"e_1_2_1_14_1","DOI":"10.1288\/00005537-199103000-00001"},{"doi-asserted-by":"publisher","key":"e_1_2_1_15_1","DOI":"10.1002\/lary.1983.93.4.410"},{"doi-asserted-by":"publisher","key":"e_1_2_1_16_1","DOI":"10.1016\/S0272-2712(18)30690-5"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989210700109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989210700109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:51:04Z","timestamp":1760957464000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989210700109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["10.1177\/019459989210700109"],"URL":"https:\/\/doi.org\/10.1177\/019459989210700109","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}