{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:18:58Z","timestamp":1771481938075,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":8327,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008635","name":"University of Texas Health Science Center at San Antonio","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:p>This study compared the degree of vasoconstriction and anesthesia obtained with cocaine vs. that obtained with a mixture of lidocaine and oxymetazoline (lido\/oxy) in healthy, male volunteers. Blood flow was evaluated by laser Doppler flowmetry. Anesthesia was measured with Semmes\u2010Weinstein monofilaments, testing both sensation threshold and pain perception. A greater decrease in blood flow was seen after the administration of lido\/oxy than after the administration of cocaine. Pain perception change was not significantly different between treatment groups at 10\u00a0minutes after removal of the medication\u2010soaked pledget, but lido\/oxy caused a greater decrease in pain perception than cocaine after 50\u00a0minutes. No significant difference in sensation threshold change was seen between treatment groups. Lidocaine with oxymetazoline is, therefore, believed to be an effective alternative to cocaine for nasal procedures.<\/jats:p>","DOI":"10.1177\/019459989310900404","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T04:51:24Z","timestamp":1485579084000},"page":"653-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["First place \u2014 resident clinical science award 1993: A comparison of cocaine vs. lidocaine with oxymetazoline for use in nasal procedures"],"prefix":"10.1002","volume":"109","author":[{"given":"Cynthia P.","family":"Tarver","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Texas Health Science Center San Antonio Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen D.","family":"Noorily","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Texas Health Science Center San Antonio Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie S.","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Texas Health Science Center San Antonio Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198306000-00003"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199009000-00024"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198912073212301"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90186-8"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488909125529"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198602000-00028"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210700511"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1136\/rapm-00115550-199116050-00006","article-title":"Comparison between ropivacaine and bupivacaine after subcutaneous injection in pigs: cutaneous blood flow and surgical bleeding","volume":"16","author":"Guinard JP","year":"1991","journal-title":"Reg Anesth"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0712(21)01104-5"},{"key":"e_1_2_1_11_1","first-page":"63","volume-title":"The nose: upper airway physiology and the atmospheric environment","author":"Cauna N","year":"1982"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.5935\/0305-7518.19860028"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489009107425"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989310900404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989310900404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:49:15Z","timestamp":1760953755000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989310900404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1177\/019459989310900404"],"URL":"https:\/\/doi.org\/10.1177\/019459989310900404","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]},"assertion":[{"value":"1993-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1993-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}