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This phenomenon did not appear to be due to suppressor activity of adenoidal T cells because T cells from other sources appeared to effectively result in adenoidal B cell maturation, even in the presence of adenoidal T cells. Both tonsils and adenoids appear to have defective IL\u20102 production, in response to both mitogens and specific antigens. It is hypothesized that a cytokine(s) may be released in adenoids that downregulate IL\u20102 production and result in immune suppression in the adenoids of children with recurrent otitis media and chronic sinusitis.<\/jats:p>","DOI":"10.1177\/019459989310900410","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T04:51:24Z","timestamp":1485579084000},"page":"693-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Are thymus\u2010derived lymphocytes (t cells) defective in the nasopharyngeal and palatine tonsils of children?"],"prefix":"10.1002","volume":"109","author":[{"given":"Joel M.","family":"Bernstein","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Pediatrics Children's Hospital of Buffalo Buffalo New York"},{"name":"State University of New York at Buffalo Divisions of Infectious Disease Children's Hospital of Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Rich","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Children's Hospital of Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Odziemiec","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Children's Hospital of Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ballow","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Children's Hospital of Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"28","volume-title":"Bienenstock J, ed. 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