{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:48:08Z","timestamp":1771303688366,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":8266,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005193","name":"American Academy of Otolaryngology-Head and Neck Surgery","doi-asserted-by":"publisher","award":["(F59002)"],"award-info":[{"award-number":["(F59002)"]}],"id":[{"id":"10.13039\/100005193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:p>Several studies have demonstrated that noise exposure may result in local vasoconstriction of cochlear vessels. The subsequent decrease in cochlear blood flow may lead to hypoxia and predispose to the formation of free oxygen radicals (FORs). If hypoxia occurs in response to noise exposure, then drugs that scavenge or block the formation of FORs should protect the cochlea from damage resulting from hypoxic or ischemic events as well as noise trauma. Rats were exposed to 60 hours of continuous broad\u2010band noise (90\u00a0dB SPL) and treated with superoxide dismutase \u2014 Polyethylene glycol (SOD\u2010PEG), allopurinol, or a control vehicle. Exposure to noise resulted in significant threshold shifts at each frequency tested (3, 8, 12, and 18\u00a0kHz) as measured by tone burst\u2010evoked compound action potentials and cochlear microphonics recorded from the round window. Both of these thresholds In drug\u2010treated animals were attenuated compared with animals exposed to noise alone. These findings show that SOD\u2010PEG and allopurinol may preserve cochlear sensitivity associated with noise exposure. This suggests that noise\u2010induced damage to the cochlea may be related to the activity of FORs.<\/jats:p>","DOI":"10.1177\/019459989310900613","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T03:27:18Z","timestamp":1485574038000},"page":"1052-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["The protective effects of allopurinol and superoxide dismutase on noise\u2010induced cochlear damage"],"prefix":"10.1002","volume":"109","author":[{"given":"Michael D.","family":"Seidman","sequence":"first","affiliation":[{"name":"Otology Research Laboratory Henry Ford Hospital Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhagylakshmi G.","family":"Shivapuja","sequence":"additional","affiliation":[{"name":"Otology Research Laboratory Henry Ford Hospital Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne S.","family":"Quirk","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Wayne State University Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","volume-title":"Otolaryngology","author":"Melnick W","year":"1986"},{"key":"e_1_2_1_3_1","first-page":"1639","volume-title":"Otolaryngology","author":"Ward WD","year":"1980"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.21236\/AD0013028"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1916054"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016486509127027"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1971.00770070486002"},{"key":"e_1_2_1_8_1","first-page":"283","volume-title":"New perspectives on noise\u2010induced hearing loss","author":"Bohne BA","year":"1982"},{"key":"e_1_2_1_9_1","first-page":"23","volume-title":"New perspectives on noise\u2010induced hearing loss","author":"Lim DJ","year":"1982"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.381767"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110500402"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110500402"},{"key":"e_1_2_1_13_1","volume-title":"Noise in America: The extent of the noise problem","author":"Simpson M","year":"1981"},{"key":"e_1_2_1_14_1","volume-title":"Occupational hearing loss","author":"Ginnold RE","year":"1979"},{"key":"e_1_2_1_15_1","first-page":"24","article-title":"Leading work related diseases and injuries \u2014 United States","volume":"32","author":"Centers for Disease Control","year":"1983","journal-title":"MMWR"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(92)90079-3"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488109138504"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487909137139"},{"key":"e_1_2_1_19_1","first-page":"49","volume-title":"New perspectives on noise\u2010induced hearing loss","author":"Axelsson A","year":"1982"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00455231"},{"key":"e_1_2_1_21_1","first-page":"903","article-title":"The role of vasoconstriction in noise\u2010induced hearing loss","volume":"80","author":"Hawkins JE","year":"1971","journal-title":"Ann Otol"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197207000-00001"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90021-9"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(91)90201-J"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501173120305"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106271"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90648-X"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000128020"},{"key":"e_1_2_1_29_1","first-page":"395","article-title":"Effect of allopurinol on patients undergoing open heart surgery","volume":"43","author":"Adachi H","year":"1979","journal-title":"Jap Arc J"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.2.329"},{"key":"e_1_2_1_31_1","first-page":"91","article-title":"The free radical pathology and the microcirculators in the major central nervous system disorders","volume":"492","author":"Demopoulos HB","year":"1980","journal-title":"Acta Physiol Scand"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.6.1284"},{"key":"e_1_2_1_33_1","first-page":"145","volume-title":"Oxygen radical and their scavenger systems, Vol II. 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